在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 試劑盒
  3. 酶聯免疫試劑盒
  4. Human Interferon kappa(IFNK) ELISA kit

Human Interferon kappa(IFNK) ELISA kit

  • 中文名稱：
    人干擾素κ(IFNK)酶聯免疫試劑盒
  • 貨號：
    CSB-EL011053HU
  • 規格：
    96T/48T
  • 價格：
    ￥3600/￥2500
  • 其他：

產品詳情

  • 產品描述：
    人干擾素κ(IFNK)酶聯免疫試劑盒（CSB-EL011053HU）為雙抗夾心法ELISA試劑盒，定量檢測血清、血漿、組織勻漿樣本中的IFNK含量。IFNK即干擾素κ，是I型干擾素家族成員。它具有抗病毒、抗腫瘤和免疫調節等潛在作用。其研究機制方面，能與細胞表面受體結合，激活相關信號通路，誘導多種抗病毒蛋白產生，發揮免疫調節活性，抵御病原體入侵與腫瘤發展。試劑盒檢測范圍為15.6 pg/mL-1000 pg/mL，適用于病毒感染機制、自身免疫疾病模型構建、皮膚屏障功能研究等科研領域，還特別適用于免疫微環境分析、細胞因子網絡研究等基礎科研場景，能為探索IFNK在炎癥性疾病、腫瘤免疫調控及組織特異性免疫應答中的作用提供可靠工具。本品僅用于科研，不用于臨床診斷，產品具體參數及操作步驟詳見產品說明書。
  • 別名：
    IFN kappa ELISA Kit; IFN-kappa ELISA Kit; Ifnk ELISA Kit; IFNK_HUMAN ELISA Kit; Interferon kappa ELISA Kit
  • 縮寫：
  • Uniprot No.：
  • 種屬：
    Homo sapiens (Human)
  • 樣本類型：
    serum, plasma, tissue homogenates
  • 檢測范圍：
    15.6 pg/mL-1000 pg/mL
  • 靈敏度：
    3.9 pg/mL
  • 反應時間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測波長：
    450 nm
  • 研究領域：
    Immunology
  • 測定原理：
    quantitative
  • 測定方法：
    Sandwich
  • 精密度：
    Intra-assay Precision (Precision within an assay): CV%<8%        
    Three samples of known concentration were tested twenty times on one plate to assess.    
    Inter-assay Precision (Precision between assays): CV%<10%        
    Three samples of known concentration were tested in twenty assays to assess.      
                   
  • 線性度：
    To assess the linearity of the assay, samples were spiked with high concentrations of human IFNK in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.  
    　 Sample Serum(n=4)    
    1:1 Average % 93    
    Range % 89-97    
    1:2 Average % 85    
    Range % 80-90    
    1:4 Average % 90    
    Range % 85-94    
    1:8 Average % 98    
    Range % 94-103    
  • 回收率：
    The recovery of human IFNK spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.  
     
    Sample Type Average % Recovery Range    
    Serum (n=5) 101 97-105    
    EDTA plasma (n=4) 92 88-96    
                   
                   
  • 標準曲線：
    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.  
     
    pg/ml OD1 OD2 Average Corrected    
    1000 2.694 2.758 2.726 2.622    
    500 2.309 2.182 2.246 2.142    
    250 1.515 1.601 1.558 1.454    
    125 0.954 1.004 0.979 0.875    
    62.5 0.521 0.560 0.541 0.437    
    31.25 0.287 0.293 0.290 0.186    
    15.6 0.193 0.205 0.199 0.095    
    0 0.100 0.107 0.104 　    
  • 數據處理：
  • 貨期：
    3-5 working days

產品評價

靶點詳情

  • 功能：
    May play a role in the regulation of immune cell function. Cytokine that imparts cellular protection against viral infection in a species-specific manner. Activates the interferon-stimulated response element signaling pathway. It is able to directly modulate cytokine release from monocytes and dendritic cells. Binds heparin.
  • 基因功能參考文獻：
    1. investigation of common variable immunodeficiency (CVID) from 2 German families; report on the occurrence of a common and one novel truncating IFNK mutation in cases with CVID; the frequency distribution of c.30_31insTGTT in cases and controls as well as the observed segregation patterns in CVID families exclude IFNK mutations as major risk factor in CVID PMID: 28324805
    2. These results suggest that high-risk human papillomavirus 31 target interferon kappa to prevent Sp100 expression and identify Sp100 as an interferon-stimulated gene with anti-human papillomavirus activity. PMID: 26491169
    3. This study demonstrates that E2 proteins of high risk human papillomavirus reduce STING and IFN-kappa transcription. PMID: 24614210
    4. The viral E6 and E7 oncogenes are sufficient for interferon-kappa repression, with E6 being mainly responsible. PMID: 21849431
    5. IFN-kappa is down-regulated in cervical keratinocytes harboring HPV, which may be a contributing factor in the progression of a cervical lesion PMID: 20479716
    6. Studied IFNK single nucleotide polymorphisms in 3982 Systemic lupus erythematosus cases and 4275 controls. PMID: 20706608
    7. IFN-kappa is able to directly modulate cytokine release from monocytes and dendritic cells, inhibit inducible IL-12 release from monocytes, and bind strongly to heparin. PMID: 12391192
    8. This is the first report showing an epigenetic silencing of type I IFN after HPV16 oncogene expression PMID: 19887612

    顯示更多

    收起更多

  • 亞細胞定位：
    Secreted.
  • 蛋白家族：
    Alpha/beta interferon family
  • 組織特異性：
    Expressed in keratinocytes, monocytes and in resting dendritic cells.
  • 數據庫鏈接：

    HGNC: 21714

    OMIM: 615326

    KEGG: hsa:56832

    STRING: 9606.ENSP00000276943

    UniGene: Hs.591083



主站蜘蛛池模板： 天天澡天天揉揉av在线| 免费看成人aa片无码视频羞羞网 | 国产精品国产高清国产av| 伊人久久大香线蕉av一区二区| 日本肥老妇色xxxxx日本老妇| 欧美孕妇乳喷奶水在线观看| 国产亚洲熟妇在线视频| 亚洲成年看片在线观看| 果冻传媒18禁免费视频| 日韩人妻无码一区二区三区| 国产亚洲欧美精品永久| 无码人妻久久一区二区三区蜜桃| 久久久精品中文字幕乱码18| 欧美黑人巨大videos精品男男| 久久久久99人妻一区二区三区| 国产在线无码制服丝袜无码| 亚洲欧美在线观看品| 超碰aⅴ人人做人人爽欧美| 国産精品久久久久久久| 欧美丰满熟妇xxxx| 国色精品卡一卡2卡3卡4卡在线 | 男受被做哭激烈娇喘gv视频| 欧美牲交a欧美在线| 秋霞鲁丝无码一区二区三区| 人妻系列无码一区二区三区| 日本阿v网站在线观看中文| 久久天天躁夜夜躁狠狠躁2022 | 全黄h全肉边做边吃奶视频| 国产在线精品一区二区在线看| 欧美黑人巨大xxxxx视频| 国产精品宾馆在线精品酒店| 国产成人精品福利网站| 色婷婷五月综合欧美图片| 无码加勒比一区二区三区四区| 精品人妻av区| 高清无码一区二区在线观看吞精| 国产与黑人在线播放| 色久悠悠婷婷综合在线亚洲 | 精品国产三级a∨在线欧美| 国产熟妇搡bbbb搡bbbb搡| 国产巨大爆乳在线观看|