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  4. Human Actin-related protein 2/3 complex subunit 2(ARPC2) ELISA kit

Human Actin-related protein 2/3 complex subunit 2(ARPC2) ELISA kit

  • 中文名稱：
    人肌動蛋白相關蛋白2/3復合物亞基2(ARPC2)酶聯免疫試劑盒
  • 貨號：
    CSB-EL002127HU
  • 規格：
    96T/48T
  • 價格：
    ￥3600/￥2500
  • 其他：

產品詳情

  • 產品描述：
    人肌動蛋白相關蛋白2/3復合物亞基2(ARPC2)酶聯免疫試劑盒（CSB-EL002127HU）為雙抗夾心法ELISA試劑盒，定量檢測血清、血漿、組織勻漿、細胞裂解物樣本中的ARPC2含量。ARPC2是一個重要靶點。它在細胞的多種活動如遷移、黏附等過程中發揮關鍵作用。相關研究主要圍繞其參與的細胞骨架構建機制，探索其在疾病尤其是腫瘤發生、發展中的作用，以尋找新的治療策略和藥物作用位點。試劑盒檢測范圍為23.5 pg/mL-1500 pg/mL，適用于基礎科研中探究細胞骨架動態調控機制、腫瘤侵襲轉移研究、神經發育及免疫細胞趨化作用等領域的樣本分析，為細胞生物學、分子病理學等研究提供可靠工具。本品僅用于科研，不用于臨床診斷，產品具體參數及操作步驟詳見產品說明書。
  • 別名：
    Actin related protein 2/3 complex subunit 2 34kDa ELISA Kit; Actin related protein 2/3 complex subunit 2 ELISA Kit; Actin-related protein 2/3 complex subunit 2 ELISA Kit; ARC 34 ELISA Kit; ARC34 ELISA Kit; Arp2/3 complex 34 kDa subunit ELISA Kit; ARP2/3 protein compex subunit 34 ELISA Kit; ARPC 2 ELISA Kit; Arpc2 ELISA Kit; ARPC2_HUMAN ELISA Kit; p34 Arc ELISA Kit; p34-ARC ELISA Kit; p34Arc ELISA Kit; PNAS 139 ELISA Kit; PNAS139 ELISA Kit; PRO 2446 ELISA Kit; PRO2446 ELISA Kit
  • 縮寫：
  • Uniprot No.：
  • 種屬：
    Homo sapiens (Human)
  • 樣本類型：
    serum, plasma, tissue homogenates, cell lysates
  • 檢測范圍：
    23.5 pg/mL-1500 pg/mL
  • 靈敏度：
    5.8 pg/mL
  • 反應時間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測波長：
    450 nm
  • 研究領域：
    Signal Transduction
  • 測定原理：
    quantitative
  • 測定方法：
    Sandwich
  • 精密度：
    Intra-assay Precision (Precision within an assay): CV%<8%
    Three samples of known concentration were tested twenty times on one plate to assess.
    Inter-assay Precision (Precision between assays): CV%<10%
    Three samples of known concentration were tested in twenty assays to assess.
  • 線性度：
    To assess the linearity of the assay, samples were spiked with high concentrations of human ARPC2 in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.
    　SampleSerum(n=4)
    1:1Average %86
    Range %80-92
    1:2Average %95
    Range %90-105
    1:4Average %99
    Range %92-110
    1:8Average %91
    Range %85-98
  • 回收率：
    The recovery of human ARPC2 spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.
    Sample TypeAverage % RecoveryRange
    Serum (n=5) 9287-97
    EDTA plasma (n=4)9085-100
  • 標準曲線：
    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
    pg/mlOD1OD2AverageCorrected
    15002.201 2.122 2.162 2.011
    7501.564 1.476 1.520 1.369
    3751.007 0.953 0.980 0.829
    187.50.683 0.634 0.659 0.508
    940.492 0.453 0.473 0.322
    470.354 0.331 0.343 0.192
    23.50.246 0.239 0.243 0.092
    00.155 0.146 0.151 　
  • 數據處理：
  • 貨期：
    3-5 working days

產品評價

靶點詳情

  • 功能：
    Actin-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the mother actin filament. In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA. The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs).
  • 基因功能參考文獻：
    1. In the association analysis of 110 gastric cancer tissues, ARPC2 showed significant associations with large tumor size, lymph node invasion, and high tumor stage. In addition, ARPC2-positive patients exhibited lower RFS and OS rates compared with ARPC2-negative patients. We thus identify that ARPC2 plays an aneretic role in human gastric cancer and provided a new target for gastric cancer therapy. PMID: 28694563
    2. Downregulation of the ARP2/3 complex signaling pathway, a common final pathway for multiple signaling cascades that regulate the actin cytoskeleton, would compromise the structural stability of spines, leading to their loss. In concert with findings from deletion of the ARP2/3 complex in mice, these findings support the idea that spine deficits in the DLPFC may contribute to subcortical hyperdopaminergia in schizophrenia. PMID: 27523502
    3. Recent reports now demonstrate a novel aspect of the ARP2/3 complex and the nucleating-promoting factors in the maintenance of endothelial barrier function and junction remodeling of established endothelial cell junctions. PMID: 24621569
    4. FOXF1 repressed cell growth and expression of collagen-1 and actin-related protein 2/3 complex, subunit 2. PMID: 25260753
    5. The Arp2/3 complex is recruited to invading Rickettsia parkeri and is required for efficient invasion. PMID: 22188208
    6. Filopodia initiation: focus on the Arp2/3 complex and formins PMID: 21975549
    7. WASH is a bimodular protein and a component of the BLOC-1 complex in which the C terminus is involved in Arp2/3-mediated actin nucleation, whereas the N-terminal portion is required for its regulation and localization in the cells PMID: 20308062
    8. The actin-related protein 2 accumulated in punctate structures that formed an extensivenetwork in a region corresponding to the postition of the Golgi complex. PMID: 15793564
    9. Compared with controls, actin-related protein 2/3 level was markedly increased in brains of intractable epilepsy patients. PMID: 18708039
    10. These findings strongly suggest that defective IL10 function is central to the pathogenesis of the ulcerative colitis subtype of inflammatory bowel disease. PMID: 18836448

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  • 亞細胞定位：
    Cytoplasm, cytoskeleton. Cell projection. Cell junction, synapse, synaptosome. Nucleus.
  • 蛋白家族：
    ARPC2 family
  • 數據庫鏈接：

    HGNC: 705

    OMIM: 604224

    KEGG: hsa:10109

    STRING: 9606.ENSP00000295685

    UniGene: Hs.529303



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