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YAP1

YAP1,即yes相關蛋白1,別名Yes1 Associated Transcriptional Regulator、YAP652、YAP-12、Yes-Associated Protein YAP65 Homolog、Transcriptional Coactivator YAP1、Yes Associated Protein 123、Protein Yorkie Homolog、Yes-Associated Protein 1, 65kDa等 。它是一種轉錄共激活因子,其活性受Hippo信號通路控制,在正常組織穩態和再生中發揮重要作用,也在癌癥發生、侵襲、轉移和治療抵抗中發揮著重要作用 。YAP1的作用機制主要是通過與Hippo信號通路中的激酶級聯反應相關,影響細胞增殖和凋亡。當Hippo信號通路激活時,YAP1會被LATS1/2激酶磷酸化,導致其在細胞質中隔離和蛋白酶體降解。而當Hippo信號通路關閉時,YAP1去磷酸化并轉移到細胞核中,與轉錄因子如TEAD家族成員結合,激活下游基因的表達,從而調控細胞生長、代謝、增殖、遷移、侵襲或死亡 。此外,YAP1還參與調控組織張力和3D組織形態,通過調節皮層肌動蛋白網絡形成發揮作用 。YAP1在生物學上的意義非常廣泛,它不僅參與了組織生長和器官大小的調控,還與多種疾病的發生發展密切相關。YAP1的異常表達或功能失調與腫瘤的發生、侵襲性、轉移和治療抵抗性有關,是癌癥治療中的一個潛在靶點。此外,YAP1還參與了免疫應答、細胞接觸反應、細胞增殖和凋亡等重要生物學過程的調控 。

熱銷產品

Recombinant Human Transcriptional coactivator YAP1 (YAP1) (CSB-YP026244HU)

驗證數據

CSB-YP026244HU

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

YAP1 Antibody (CSB-PA004537)

驗證數據

CSB-PA004537

Western Blot analysis of HepG2 cells using YAP Polyclonal Antibody

CSB-PA004537

Western Blot analysis of HepG2 RAT-MUSCLE cells using YAP Polyclonal Antibody

YAP1 Antibodies

YAP1 for Homo sapiens (Human)

YAP1 Proteins

YAP1 Proteins for Homo sapiens (Human)

YAP1 Proteins for Mus musculus (Mouse)

YAP1 Proteins for Gallus gallus (Chicken)

YAP1 Proteins for Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

YAP1 Proteins for Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)

YAP1 Proteins for Rattus norvegicus (Rat)