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WWP2

NEDD4-like E3 ubiquitin-protein ligase WWP2 is a protein in humans that is encoded by WWP2 gene. E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Polyubiquitinates POU5F1 by 'Lys-63'-linked conjugation and promotes it to proteasomal degradation; in embryonic stem cells (ESCs) the ubiquitination is proposed to regulate POU5F1 protein level. Ubiquitinates EGR2 and promotes it to proteasomal degradation; in T-cells the ubiquitination inhibits activation-induced cell death. Ubiquitinates SLC11A2; the ubiquitination is enhanced by presence of NDFIP1 and NDFIP2. Ubiquitinates RPB1 and promotes it to proteasomal degradation.

WWP2 Antibodies

WWP2 for Homo sapiens (Human)

WWP2 Proteins

WWP2 Proteins for Homo sapiens (Human)

WWP2 Proteins for Mus musculus (Mouse)



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