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VIM

VIM蛋白全稱波形蛋白,是Ⅲ型中間纖維的主要成分,構成細胞骨架網絡維持細胞機械穩定性。VIM在上皮細胞損傷修復時異常升高,促進細胞形態改變與遷移能力,其過度表達被視為上皮-間質轉化的標志物,與乳腺癌、胰腺癌的侵襲轉移密切相關。在纖維化疾病領域,肺、肝組織中的VIM沉積與器官硬化進程直接相關,阿爾茨海默病患者腦脊液內也檢測到特異性片段積累。
針對VIM的治療策略多聚焦于抑制其病理聚合。小分子化合物Withaferin A從天然植物提取,可破壞VIM纖維結構,在動物模型中有效減緩腫瘤轉移和肺纖維化進展,但存在肝腎毒性問題。單克隆抗體VN-18.2通過阻斷VIM與細胞膜整合素互作,已完成黑色素瘤治療的臨床前評估。近年來利用CRISPR技術敲低VIM表達改善心肌纖維化的研究引發關注,其載體遞送效率仍是轉化難點。

熱銷產品

Recombinant Human Vimentin (VIM) (CSB-EP025857HUc7)

驗證數據

CSB-EP025857HUc7

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

VIM Recombinant Monoclonal Antibody (CSB-RA025857MA1HU)

驗證數據

CSB-RA025857MA1HU

IHC image of CSB-RA025857MA1HU diluted at 1:40 and staining in paraffin-embedded human tonsil tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-Rabbit IgG labeled by HRP and visualized using 0.05% DAB.

CSB-RA025857MA1HU

IHC image of CSB-RA025857MA1HU diluted at 1:40 and staining in paraffin-embedded human endometrial cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-Rabbit IgG labeled by HRP and visualized using 0.05% DAB.

CSB-RA025857MA1HU

Immunofluorescence staining of NIH/3T3 cell with CSB-RA025857MA1HU at 1:40, counter-stained with DAPI. The cells were fixed in 4% formaldehyde and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4C. The secondary antibody was FITC-conjugated AffiniPure Goat Anti-Rabbit IgG(H+L).

Human vimentin,VIM ELISA Kit (CSB-E08982h)

驗證數據

CSB-E08982h 標準曲線

貨號:CSB-E08982h

規格:96T/48T

靈敏度:7.8 pg/mL

檢測范圍:31.25 pg/mL-2000 pg/mL

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

VIM Antibodies

VIM for Homo sapiens (Human)

VIM for H, M, R

VIM Proteins

VIM Proteins for Mus musculus (Mouse)

VIM Proteins for Rattus norvegicus (Rat)

VIM Proteins for Bos taurus (Bovine)

VIM Proteins for Homo sapiens (Human)

VIM Proteins for Gallus gallus (Chicken)

VIM Proteins for Sus scrofa (Pig)

VIM Proteins for Chlorocebus aethiops (Green monkey) (Cercopithecus aethiops)

VIM Proteins for Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus)

VIM Proteins for Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)

VIM Proteins for Mesocricetus auratus (Golden hamster)

VIM Proteins for Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)

VIM Proteins for Pan troglodytes (Chimpanzee)

VIM Proteins for Cyprinus carpio (Common carp)

VIM Proteins for Ovis aries (Sheep)

VIM Proteins for MO-Mus musculus (Mouse)

VIM ELISA Kit

VIM ELISA Kit for Homo sapiens (Human)

VIM ELISA Kit for Rattus norvegicus (Rat)



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