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TRIM25

E3 ubiquitin/ISG15 ligase TRIM25 is a protein in humans that is encoded by TRIM25 gene. Functions as a ubiquitin E3 ligase and as an ISG15 E3 ligase. Involved in innate immune defense against viruses by mediating ubiquitination of DDX58. Mediates 'Lys-63'-linked polyubiquitination of the DDX58 N-terminal CARD-like region which is crucial for triggering the cytosolic signal transduction that leads to the production of interferons in response to viral infection. Promotes ISGylation of 14-3-3 sigma (SFN), an adapter protein implicated in the regulation of a large spectrum signaling pathway. Mediates estrogen action in various target organs. Mediates the ubiquitination and subsequent proteasomal degradation of ZFHX3

TRIM25 Antibodies

TRIM25 for Homo sapiens (Human)

TRIM25 Proteins

TRIM25 Proteins for Homo sapiens (Human)

TRIM25 Proteins for Mus musculus (Mouse)



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