TMED4
TMED4,即跨膜p24運輸蛋白4。別名HNLF、ERS25、p24a3。TMED4在多種細胞過程中發揮作用,包括內質網應激反應、熱休克反應、細胞凋亡以及囊泡蛋白運輸,主要在早期分泌途徑中。
TMED4的作用機制涉及內質網應激(ERS)的調節,通過IRE1α-XBP1信號通路和NRF2相關的抗氧化反應,促進調節性T細胞(Treg)中活性氧(ROS)的穩態,維持Treg細胞Foxp3的表達及抑制功能。TMED4對于維持Treg細胞的穩定性和功能至關重要,其缺失會導致Treg細胞中Foxp3穩定性降低,影響Treg細胞的抑制功能,進而可能導致T細胞過度激活和炎癥反應加劇。TMED4還可能通過ER相關的降解(ERAD)系統抑制IRE1α的蛋白酶體降解。TMED4的功能異常與多種疾病相關,包括神經細胞脂褐素沉積癥8型。
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The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA639635(TMED4 Antibody) at dilution 1/45, on the right is treated with fusion protein. (Original magnification: ×200)

The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using CSB-PA639635(TMED4 Antibody) at dilution 1/45, on the right is treated with fusion protein. (Original magnification: ×200)

Gel: 8%SDS-PAGE,Lysate: 40 μg,Lane 1-5: HepG2 cells, K562 cells, Hela cells, A549 cells, Mouse intestines tissue,Primary antibody: CSB-PA639635(TMED4 Antibody) at dilution 1/800 dilution,Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution,Exposure time: 1 minute
TMED4 Antibodies
TMED4 for Homo sapiens (Human)
產品貨號 | 產品名稱 | 種屬反應性 | 應用類型 |
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CSB-PA023660GA01HU | TMED4 Antibody | Human,Mouse,Rat | ELISA,WB |
CSB-PA639635 | TMED4 Antibody | Human,Mouse | ELISA,WB,IHC |
TMED4 Proteins
TMED4 Proteins for Homo sapiens (Human)
產品貨號 | 產品名稱 | 來源 |
---|---|---|
CSB-YP770365HU CSB-EP770365HU CSB-BP770365HU CSB-MP770365HU CSB-EP770365HU-B |
Recombinant Human Transmembrane emp24 domain-containing protein 4 (TMED4), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |