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TLR2

TLR2,全稱Toll樣受體2,是一種重要的免疫識別蛋白,也被稱為CD284。它參與人體對病原體的識別和免疫反應(yīng),在急性炎癥、細(xì)胞信號轉(zhuǎn)導(dǎo)和細(xì)胞凋亡中發(fā)揮關(guān)鍵作用。TLR2通常與LY96蛋白協(xié)同工作,識別細(xì)菌的脂蛋白和細(xì)胞壁成分,啟動免疫應(yīng)答。其激活后可引發(fā)多種信號通路,如NF-κB和MAPK通路,進(jìn)而調(diào)節(jié)炎癥因子如TNF-α和IL-1的分泌。TLR2與多種疾病的發(fā)生發(fā)展密切相關(guān),包括類風(fēng)濕性關(guān)節(jié)炎、紅斑狼瘡、糖尿病和心血管疾病等。針對TLR2的藥物研發(fā)已成為熱點(diǎn),例如清華大學(xué)尹航團(tuán)隊(duì)研發(fā)的小分子CU-T12-9可作為Toll樣受體調(diào)節(jié)劑,用于開發(fā)治療類風(fēng)濕性關(guān)節(jié)炎和紅斑狼瘡等免疫疾病的疫苗。此外,TLR2拮抗劑的研究也取得進(jìn)展,有望為心血管疾病等提供新的治療策略。

熱銷產(chǎn)品

Recombinant Human Toll-like receptor 2 (TLR2), partial (CSB-EP023601HU1)

驗(yàn)證數(shù)據(jù)

CSB-EP023601HU1

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

CSB-EP023601HU1

Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP023601HU1 could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) TLR2.

CSB-EP023601HU1

Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP023601HU1 could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) TLR2.

TLR2 Antibody (CSB-PA205006)

驗(yàn)證數(shù)據(jù)

CSB-PA205006

The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA205006(TLR2 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: ×200)

Human toll-like receptor 2,TLR2 ELISA Kit (CSB-E11781h)

驗(yàn)證數(shù)據(jù)

CSB-E11781h 標(biāo)準(zhǔn)曲線

貨號:CSB-E11781h

規(guī)格:96T/48T

靈敏度:0.078 ng/mL

檢測范圍:0.312 ng/mL-20 ng/mL

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

TLR2 Antibodies

TLR2 for Homo sapiens (Human)

TLR2 Proteins

TLR2 Proteins for Ovis aries (Sheep)

TLR2 Proteins for Macaca mulatta (Rhesus macaque)

TLR2 Proteins for Giraffa camelopardalis (Giraffe)

TLR2 Proteins for Gorilla gorilla gorilla (Lowland gorilla)

TLR2 Proteins for Capra ibex (Ibex)

TLR2 Proteins for Bison bison (American bison) (Bos bison)

TLR2 Proteins for Pan troglodytes (Chimpanzee)

TLR2 Proteins for Pan paniscus (Pygmy chimpanzee) (Bonobo)

TLR2 Proteins for Bos indicus (Zebu)

TLR2 Proteins for Canis familiaris (Dog) (Canis lupus familiaris)

TLR2 Proteins for Equus caballus (Horse)

TLR2 Proteins for Bos taurus (Bovine)

TLR2 Proteins for Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)

TLR2 Proteins for Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus)

TLR2 Proteins for Mus musculus (Mouse)

TLR2 Proteins for Capra hircus (Goat)

TLR2 Proteins for Bubalus bubalis (Domestic water buffalo)

TLR2 Proteins for Boselaphus tragocamelus (Nilgai)

TLR2 Proteins for Homo sapiens (Human)

TLR2 ELISA Kit

TLR2 ELISA Kit for Homo sapiens (Human)



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