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TFR2

TFR2,即轉鐵蛋白受體2,別名HFE3、TFRC2。它是一種單跨膜蛋白,屬于轉鐵蛋白受體樣家族的成員,主要在肝臟和腸道細胞中表達。TFR2的作用機制涉及調(diào)節(jié)細胞對結合轉鐵蛋白的鐵的攝取,可能參與鐵代謝、肝細胞功能和紅細胞分化。TFR2在鐵穩(wěn)態(tài)調(diào)節(jié)中發(fā)揮重要作用,其表達水平不受細胞內(nèi)鐵狀況的調(diào)節(jié),且在肝細胞、紅系前體細胞、K562細胞和HepG2細胞中高水平表達。TFR2的突變可導致遺傳性血色病III型的發(fā)生,這表明它在鐵代謝中的重要性。TFR2還可能在紅系前體細胞的分化發(fā)育中發(fā)揮作用,是紅系前體細胞的一種分子標志。

熱銷產(chǎn)品

TFR2 Antibody (CSB-PA14729A0Rb)

驗證數(shù)據(jù)

CSB-PA14729A0Rb

IHC image of CSB-PA14729A0Rb diluted at 1:200 and staining in paraffin-embedded human liver cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

CSB-PA14729A0Rb

IHC image of CSB-PA14729A0Rb diluted at 1:200 and staining in paraffin-embedded human liver tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

CSB-PA14729A0Rb

Immunofluorescence staining of MCF-7 cells with CSB-PA14729A0Rb at 1:66, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).

TFR2 Antibodies

TFR2 for Homo sapiens (Human)

TFR2 Proteins

TFR2 Proteins for Homo sapiens (Human)



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