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TERF2

Telomeric repeat-binding factor 2 is a protein in humans that is encoded by TERF2 gene. Binds the telomeric double-stranded 5'-TTAGGG-3' repeat and plays a central role in telomere maintenance and protection against end-to-end fusion of chromosomes. In addition to its telomeric DNA-binding role, required to recruit a number of factors and enzymes required for telomere protection, including the shelterin complex, TERF2IP/RAP1 and DCLRE1B/Apollo. Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded 5'-TTAGGG-3' repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways.

TERF2 Antibodies

TERF2 for Homo sapiens (Human)

TERF2 Proteins

TERF2 Proteins for Mus musculus (Mouse)

TERF2 Proteins for Homo sapiens (Human)

TERF2 Proteins for Gallus gallus (Chicken)



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