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SV2A

SV2A,即突觸囊泡蛋白2A,它是一種在中樞神經(jīng)系統(tǒng)的神經(jīng)元中特異性表達(dá)的膜蛋白。SV2A主要在突觸囊泡上發(fā)揮作用,參與調(diào)節(jié)神經(jīng)遞質(zhì)的釋放和囊泡的循環(huán)過(guò)程,對(duì)維持突觸功能至關(guān)重要。其作用機(jī)制涉及與Ca2+敏感蛋白synaptotagmin-1的相互作用,以及可能的ATP結(jié)合和轉(zhuǎn)運(yùn)功能,影響突觸前膜的遞質(zhì)釋放概率和囊泡的備釋放池大小。SV2A還可能是抗癲癇藥物如左乙拉西坦的靶點(diǎn),通過(guò)調(diào)節(jié)神經(jīng)遞質(zhì)釋放來(lái)影響神經(jīng)系統(tǒng)的興奮性平衡。在生物學(xué)意義上,SV2A的表達(dá)變化與癲癇等神經(jīng)系統(tǒng)疾病的發(fā)生發(fā)展相關(guān),是研究神經(jīng)遞質(zhì)釋放和相關(guān)疾病機(jī)制的重要分子。

熱銷(xiāo)產(chǎn)品

Recombinant Bovine Synaptic vesicle glycoprotein 2A (SV2A), partial (CSB-EP022978BO)

驗(yàn)證數(shù)據(jù)

CSB-EP022978BO

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

SV2A Antibody (CSB-PA117413)

驗(yàn)證數(shù)據(jù)

CSB-PA117413

The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA117413(SV2A Antibody) at dilution 1/25, on the right is treated with synthetic peptide. (Original magnification: ×200)

CSB-PA117413

The image on the left is immunohistochemistry of paraffin-embedded Human lung cancer tissue using CSB-PA117413(SV2A Antibody) at dilution 1/25, on the right is treated with synthetic peptide. (Original magnification: ×200)

SV2A Antibodies

SV2A for Homo sapiens (Human)

SV2A Proteins

SV2A Proteins for Homo sapiens (Human)