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STAT3

STAT3,即信號轉導和轉錄激活因子3,別名包括急性調節蛋白、信號轉導激活因子、亞油酸誘導蛋白等。STAT3是一種轉錄因子,廣泛存在于多種細胞類型中,由人體細胞自身的基因編碼。其作用機制主要是在細胞接收到外部信號,如細胞因子、生長因子或其他刺激后,被激活的酪氨酸激酶磷酸化,形成二聚體,隨后轉移到細胞核內調控特定基因的表達。STAT3的激活涉及JAK/STAT、IL-6/STAT3等信號通路,其中Janus激酶(JAK)首先被激活并磷酸化STAT3,導致其同源二聚化和核內轉位。STAT3在生物學上的意義非常廣泛,它參與調節細胞的多種生理過程,包括細胞增殖、分化、遷移、凋亡以及免疫應答等。STAT3的激活對于維持細胞穩態和適應外界變化至關重要。此外,STAT3在多種疾病的發生發展中也扮演著關鍵角色,尤其是在腫瘤發展中,STAT3的持續激活與腫瘤細胞的增殖、存活、血管生成和免疫逃逸等密切相關。因此,STAT3成為了癌癥治療中的一個重要靶點。在自身免疫性疾病、炎癥反應和組織修復中,STAT3的調節作用同樣不容忽視,靶向STAT3的干預策略可能為這些疾病的治療提供新的途徑。

熱銷產品

Recombinant Human Signal transducer and activator of transcription 3 (STAT3),Biotinylated (CSB-EP022812HU(A4)-B)

驗證數據

CSB-EP022812HU(A4)-B

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

STAT3 Recombinant Monoclonal Antibody (CSB-RA546821A0HU)

驗證數據

CSB-RA546821A0HU

Overlay histogram showing Hela cells stained with CSB-RA546821A0HU (red line) at 1:50. The cells were fixed with 70% Ethylalcohol (18h) and then incubated in 10% normal goat serum to block non-specific protein-protein interactions followedby the antibody (1μg/1*106 cells) for 1 h at 4℃.The secondary antibody used was FITC-conjugated goat anti-rabbit IgG (H+L) at 1/200 dilution for 30min at 4℃. Control antibody (green line) was Rabbit IgG (1μg/1*106 cells) used under the same conditions. Acquisition of >10,000 events was performed.

STAT3 Antibodies

STAT3 for Homo sapiens (Human)

STAT3 Proteins

STAT3 Proteins for Homo sapiens (Human)

STAT3 Proteins for Mus musculus (Mouse)

STAT3 Proteins for Rattus norvegicus (Rat)

STAT3 Proteins for Bos taurus (Bovine)

STAT3 Proteins for Sus scrofa (Pig)

STAT3 Proteins for Gallus gallus (Chicken)