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SRSF1

Serine/arginine-rich splicing factor 1 is a protein in humans that is encoded by SRSF1 gene. Plays a role in preventing exon skipping, ensuring the accuracy of splicing and regulating alternative splicing. Interacts with other spliceosomal components, via the RS domains, to form a bridge between the 5'- and 3'-splice site binding components, U1 snRNP and U2AF. Can stimulate binding of U1 snRNP to a 5'-splice site-containing pre-mRNA. Binds to purine-rich RNA sequences, either the octamer, 5'-RGAAGAAC-3' (r=A or G) or the decamers, AGGACAGAGC/AGGACGAAGC. Binds preferentially to the 5'-CGAGGCG-3' motif in vitro. Three copies of the octamer constitute a powerful splicing enhancer in vitro, the ASF/SF2 splicing enhancer (ASE) which can specifically activate ASE-dependent splicing. Isoform ASF-2 and isoform ASF-3 act as splicing repressors.

SRSF1 Antibodies

SRSF1 for Homo sapiens (Human)

SRSF1 Proteins

SRSF1 Proteins for Bos taurus (Bovine)

SRSF1 Proteins for Sus scrofa (Pig)

SRSF1 Proteins for Pongo abelii (Sumatran orangutan)

SRSF1 Proteins for Gallus gallus (Chicken)

SRSF1 Proteins for Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)

SRSF1 Proteins for Mus musculus (Mouse)

SRSF1 Proteins for Homo sapiens (Human)

SRSF1 ELISA Kit

SRSF1 ELISA Kit for Homo sapiens (Human)



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