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SMARCA2

SMARCA2全稱為SWI/SNF相關(guān)基質(zhì)相關(guān)肌動(dòng)蛋白依賴的染色質(zhì)調(diào)控因子A2,也被稱為BRM或SNF2L2。SMARCA2屬于SWI/SNF染色質(zhì)重塑復(fù)合物核心成員,通過(guò)調(diào)節(jié)染色質(zhì)結(jié)構(gòu)動(dòng)態(tài)變化影響基因轉(zhuǎn)錄活性,在細(xì)胞分化、增殖及DNA損傷修復(fù)中起關(guān)鍵作用。SMARCA2功能異常與肺癌、肝癌、卵巢癌等多種實(shí)體瘤密切相關(guān),其表達(dá)缺失可能導(dǎo)致腫瘤抑制因子失活或致癌通路異常激活。近年來(lái)針對(duì)SMARCA2的藥物開發(fā)聚焦于表觀遺傳調(diào)控領(lǐng)域,例如利用PROTAC技術(shù)開發(fā)靶向降解劑,或通過(guò)抑制其ATP酶活性恢復(fù)抑癌功能。

熱銷產(chǎn)品

Recombinant Human Probable global transcription activator SNF2L2 (SMARCA2), partial,Biotinylated (CSB-EP021799HU-B)

驗(yàn)證數(shù)據(jù)

CSB-EP021799HU-B

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

SMARCA2 Antibody (CSB-PA021799LA01HU)

驗(yàn)證數(shù)據(jù)

CSB-PA021799LA01HU

Chromatin Immunoprecipitation Hela (1.1*106) were cross-linked with formaldehyde, sonicated, and immunoprecipitated with 4µg anti-SMARCA2 or a control normal rabbit IgG. The resulting ChIP DNA was quantified using real-time PCR with primers (CSB-PP021799HU) against the ESR1 pS2 promoter.

CSB-PA021799LA01HU

Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA021799LA01HU at dilution of 1:100

CSB-PA021799LA01HU

Immunohistochemistry of paraffin-embedded human pancreatic cancer using CSB-PA021799LA01HU at dilution of 1:100

SMARCA2 Antibodies

SMARCA2 for Homo sapiens (Human)