SLC13A5
SLC13A5,全名為solute carrier family 13 member 5,常見別名為Na+/citrate cotransporter或mIndy。該蛋白主要參與檸檬酸鹽的轉(zhuǎn)運,與能量代謝密切相關(guān)。SLC13A5在多種組織中表達,尤其在肝臟、腎臟和小腸中發(fā)揮重要作用。研究發(fā)現(xiàn),SLC13A5與肥胖、胰島素抵抗和非酒精性脂肪肝?。∟AFLD)等代謝性疾病密切相關(guān)。目前,針對脂質(zhì)代謝紊亂引起的代謝性疾病尤其是NAFLD尚無臨床治療特效藥,因此SLC13A5成為潛在的治療靶點。已有研究表明,通過調(diào)節(jié)SLC13A5的表達或活性,可以有效改善代謝綜合征的癥狀。此外,SLC13A5還與某些癌癥的發(fā)生發(fā)展有關(guān),因此其在腫瘤治療中的應(yīng)用也備受關(guān)注。目前,針對SLC13A5的藥物研發(fā)尚處于早期階段,但已有多個研究團隊在探索其作為治療代謝性疾病和癌癥的潛在價值。
熱銷產(chǎn)品
SLC13A5 Antibody (CSB-PA768239LA01HU)
驗證數(shù)據(jù)

Western Blot
Positive WB detected in: HepG2 whole cell lysate, Rat liver tissue, Mouse heart tissue
All lanes: SLC13A5 antibody at 2.7μg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 64, 59, 62 kDa
Observed band size: 64, 59 kDa

Immunohistochemistry of paraffin-embedded human liver tissue using CSB-PA768239LA01HU at dilution of 1:100

Immunofluorescent analysis of HepG2 cells using CSB-PA768239LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
SLC13A5 Antibodies
SLC13A5 for Homo sapiens (Human)
產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
---|---|---|---|
CSB-PA768239LA01HU | SLC13A5 Antibody | Human, Mouse, Rat | ELISA, WB, IHC, IF |
CSB-PA768239LB01HU | SLC13A5 Antibody, HRP conjugated | Human | ELISA |
CSB-PA768239LC01HU | SLC13A5 Antibody, FITC conjugated | Human | |
CSB-PA768239LD01HU | SLC13A5 Antibody, Biotin conjugated | Human | ELISA |
SLC13A5 Proteins
SLC13A5 Proteins for Homo sapiens (Human)
產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
---|---|---|
CSB-YP768239HU CSB-EP768239HU CSB-BP768239HU CSB-MP768239HU CSB-EP768239HU-B |
Recombinant Human Solute carrier family 13 member 5 (SLC13A5), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |