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SIGMAR1

SIGMAR1 is a protein in humans that is encoded by SIGMAR1 gene. Functions in lipid transport from the endoplasmic reticulum and is involved in a wide array of cellular functions probably through regulation of the biogenesis of lipid microdomains at the plasma membrane. Involved in the regulation of different receptors it plays a role in BDNF signaling and EGF signaling. Also regulates ion channels like the potassium channel and could modulate neurotransmitter release. Plays a role in calcium signaling through modulation together with ANK2 of the ITP3R-dependent calcium efflux at the endoplasmic reticulum. Plays a role in several other cell functions including proliferation, survival and death. Originally identified for its ability to bind various psychoactive drugs it is involved in learning processes, memory and mood alteration. Necessary for proper mitochondrial axonal transport in motor neurons, in particular the retrograde movement of mitochondria. Plays a role in protecting cells against oxidative stress-induced cell death via its interaction with RNF112 (By similarity).

SIGMAR1 Antibodies

SIGMAR1 for Homo sapiens (Human)

SIGMAR1 Proteins

SIGMAR1 Proteins for Mus musculus (Mouse)

SIGMAR1 Proteins for Trichosurus vulpecula (Brush-tailed possum)

SIGMAR1 Proteins for Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)

SIGMAR1 Proteins for Xenopus laevis (African clawed frog)

SIGMAR1 Proteins for Taricha granulosa (Roughskin newt)

SIGMAR1 Proteins for Mustela erminea (Ermine)

SIGMAR1 Proteins for Gallus gallus (Chicken)

SIGMAR1 Proteins for Cavia porcellus (Guinea pig)

SIGMAR1 Proteins for Danio rerio (Zebrafish) (Brachydanio rerio)

SIGMAR1 Proteins for Homo sapiens (Human)

SIGMAR1 Proteins for Rattus norvegicus (Rat)

SIGMAR1 Proteins for Bos taurus (Bovine)



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