SIGLEC15
SIGLEC15，全稱唾液酸結(jié)合免疫球蛋白樣凝集素-15，是一種在腫瘤微環(huán)境中高表達(dá)的蛋白。它主要在多種腫瘤細(xì)胞和與腫瘤相關(guān)的巨噬細(xì)胞中表達(dá)，而在正常組織和免疫細(xì)胞中表達(dá)量很低。SIGLEC15具有與PD-L1類似的免疫調(diào)節(jié)功能，但兩者的表達(dá)是互斥的，這使其成為抗PD-1/PD-L1耐藥患者的一個(gè)潛在治療靶點(diǎn)。目前，first-in-class的anti-Siglec-15單克隆抗體NC318的初步臨床數(shù)據(jù)令人鼓舞，為對(duì)抗PD-1/PD-L1耐藥的腫瘤患者提供了新的治療選擇。此外，研究發(fā)現(xiàn)SIGLEC-15在原發(fā)性中樞神經(jīng)系統(tǒng)淋巴瘤（PCNSL）患者預(yù)后生存期中與腫瘤周圍巨噬細(xì)胞的表達(dá)水平有顯著相關(guān)性，這可能為腫瘤患者預(yù)后制定/優(yōu)化治療方案提供了可靠的參考。目前，ACROBiosystems自主開發(fā)了一系列Siglec-15蛋白，其生物活性經(jīng)多種技術(shù)驗(yàn)證，并獲得客戶良好反饋，為相關(guān)研究提供了有力支持。
熱銷產(chǎn)品
驗(yàn)證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Activity
Measured by its binding ability in a functional ELISA.Immobilized Human SIGLEC15 at 5 μg/ml can bind Anti-SIGLEC15 recombinant antibody(CSB-RA761623MA3HU). The EC50 is 12.42-16.08 ng/mL.
SIGLEC15 Antibody (CSB-PA975446)
驗(yàn)證數(shù)據(jù)
The image on the left is immunohistochemistry of paraffin-embedded Human tonsil tissue using CSB-PA975446(SIGLEC15 Antibody) at dilution 1/35, on the right is treated with synthetic peptide. (Original magnification: ×200)
The image on the left is immunohistochemistry of paraffin-embedded Human prostate cancer tissue using CSB-PA975446(SIGLEC15 Antibody) at dilution 1/35, on the right is treated with synthetic peptide. (Original magnification: ×200)el: 12%SDS-PAGE, Lysate: 60 μg, Lane: Mouse bladder tissue, Primary antibody: CSB-PA975446(SIGLEC15 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 5 seconds
SIGLEC15 Antibodies
SIGLEC15 for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA975446 | SIGLEC15 Antibody | Human | ELISA,IHC |
| CSB-PA064103 | SIGLEC15 Antibody | Human | ELISA,IHC |
| CSB-PA761623LA01HU | SIGLEC15 Antibody | Human | ELISA |
| CSB-PA761623LD01HU | SIGLEC15 Antibody, Biotin conjugated | Human | ELISA |
| CSB-PA761623LC01HU | SIGLEC15 Antibody, FITC conjugated | Human | |
| CSB-PA761623LB01HU | SIGLEC15 Antibody, HRP conjugated | Human | ELISA |
SIGLEC15 Proteins
SIGLEC15 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP761623HU CSB-BP761623HU CSB-EP761623HU-B |
Recombinant Human Sialic acid-binding Ig-like lectin 15 (SIGLEC15), partial | Yeast Baculovirus In Vivo Biotinylation in E.coli |
| CSB-EP761623HU | Recombinant Human Sialic acid-binding Ig-like lectin 15 (SIGLEC15), partial | E.coli |
| CSB-MP761623HU | Recombinant Human Sialic acid-binding Ig-like lectin 15 (SIGLEC15), partial (Active) | Mammalian cell |
