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SETD7

Histone-lysine N-methyltransferase SETD7 is a protein in humans that is encoded by SETD7 gene. Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes such as collagenase or insulin. Recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription. Has also methyltransferase activity toward non-histone proteins such as p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the [KR]-[STA]-K in substrate proteins. Monomethylates 'Lys-189' of TAF10, leading to increase the affinity of TAF10 for RNA polymerase II. Monomethylates 'Lys-372' of p53/TP53, stabilizing p53/TP53 and increasing p53/TP53-mediated transcriptional activation.

SETD7 Antibodies

SETD7 for Homo sapiens (Human)

SETD7 Proteins

SETD7 Proteins for Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)

SETD7 Proteins for Danio rerio (Zebrafish) (Brachydanio rerio)

SETD7 Proteins for Halocynthia roretzi (Sea squirt)

SETD7 Proteins for Homo sapiens (Human)

SETD7 Proteins for Mus musculus (Mouse)



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