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SELP

SELP,全稱為selectin P (granule membrane protein 140kDa, antigen CD62),是一種存在于血小板α顆粒和內(nèi)皮細胞Weibel-Palade小體中的跨膜糖蛋白。它也被稱為P-選擇素、GMP140、CD62P等。SELP蛋白在炎癥反應中發(fā)揮著重要作用,介導中性粒細胞和單核細胞與內(nèi)皮細胞的初始粘附相互作用;在止血過程中,活化的血小板與中性粒細胞和單核細胞相互作用。SELP蛋白的表達和功能與多種疾病的發(fā)生發(fā)展密切相關,包括腎臟疾病、甲狀腺疾病、腫瘤等。近年來,研究發(fā)現(xiàn)SELP蛋白參與了多種腎臟疾病的病理生理過程,如腎缺血再灌注損傷、糖尿病腎病、慢性腎臟病及腎癌等。SELP蛋白的抗氧化活性可能在腎臟疾病的防治中發(fā)揮重要作用。此外,SELP蛋白的表達和功能也與甲狀腺疾病、腫瘤等密切相關。在藥物研發(fā)方面,針對SELP蛋白的抗體和重組蛋白等已被廣泛應用于基礎研究和臨床診斷中,并成為潛在的治療靶點。

熱銷產(chǎn)品

Recombinant Human P-selectin (SELP), partial (CSB-MP020978HU)

驗證數(shù)據(jù)

CSB-MP020978HU

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

SELP Antibody (CSB-PA020978LA01HU)

驗證數(shù)據(jù)

CSB-PA020978LA01HU

Immunofluorescence staining of HepG2 cells with CSB-PA020978LA01HU at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).

Human P-Selectin ELISA kit (CSB-E04708h)

驗證數(shù)據(jù)

CSB-E04708h 標準曲線

貨號:CSB-E04708h

規(guī)格:96T/48T

靈敏度:0.225 ng/mL

檢測范圍:0.9 ng/mL-60 ng/mL

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

SELP Antibodies

SELP for Homo sapiens (Human)

SELP Proteins

SELP Proteins for Ovis aries (Sheep)

SELP Proteins for Rattus norvegicus (Rat)

SELP Proteins for Mus musculus (Mouse)

SELP Proteins for Bos taurus (Bovine)

SELP Proteins for Homo sapiens (Human)

SELP ELISA Kit

SELP ELISA Kit for Homo sapiens (Human)

SELP ELISA Kit for Mus musculus (Mouse)

SELP ELISA Kit for Rattus norvegicus (Rat)