PTK6
PTK6,全稱為蛋白酪氨酸激酶6,也被稱為BRK(乳腺癌激酶)。該蛋白主要存在于細胞質(zhì)中,不依賴于受體,參與上皮組織的細胞內(nèi)信號轉(zhuǎn)導(dǎo)。PTK6在乳腺上皮細胞中的過度表達會導(dǎo)致細胞對表皮生長因子的敏感性增加,進而形成部分轉(zhuǎn)化表型。它在一些乳腺癌中表達水平較高,但在正常乳腺組織中未檢測到表達。PTK6與多種癌癥的發(fā)展密切相關(guān),如乳腺癌、前列腺癌等,因此在癌癥治療中成為一個潛在靶點。近年來,研究人員開發(fā)了針對PTK6的降解/破壞化合物,用于治療PTK6介導(dǎo)的疾病。此外,PTK6也被發(fā)現(xiàn)與細胞分化、凋亡等過程有關(guān),其在多種疾病中的作用機制仍在深入研究中。針對PTK6的藥物研發(fā)正在逐步推進,有望為相關(guān)疾病的治療提供新的策略。
熱銷產(chǎn)品
PTK6 Antibody (CSB-PA614448LA01HU)
驗證數(shù)據(jù)

Western Blot
Positive WB detected in: MCF-7 whole cell lysate, Hela whole cell lysate
All lanes: PTK6 antibody at 2.4µg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 52, 15 kDa
Observed band size: 52 kDa

Immunofluorescent analysis of MCF-7 cells using CSB-PA614448LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
PTK6 Antibodies
PTK6 for Homo sapiens (Human)
產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
---|---|---|---|
CSB-PA018995GA01HU | PTK6 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
CSB-PA040087 | Phospho-PTK6 (Y447) Antibody | Human | WB, IF, ELISA |
CSB-PA040088 | PTK6 Antibody | Human | IF, ELISA |
CSB-PA040089 | PTK6 Antibody | Human,Mouse | WB, IHC, IF, ELISA |
CSB-PA142965 | PTK6 Antibody | Human,Mouse | ELISA,IHC |
CSB-PA997274 | PTK6 Antibody | Human,Mouse | ELISA,IHC |
CSB-PA614448LA01HU | PTK6 Antibody | Human | ELISA, WB, IF |
CSB-PA614448LB01HU | PTK6 Antibody, HRP conjugated | Human | ELISA |
CSB-PA614448LD01HU | PTK6 Antibody, Biotin conjugated | Human | ELISA |
PTK6 Proteins
PTK6 Proteins for Homo sapiens (Human)
產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
---|---|---|
CSB-YP614448HU CSB-EP614448HU CSB-BP614448HU CSB-MP614448HU CSB-EP614448HU-B |
Recombinant Human Protein-tyrosine kinase 6 (PTK6) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |