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PTGER4

PTGER4,全稱為前列腺素E受體4(亞型EP4),是一種在人體內(nèi)發(fā)揮重要作用的蛋白質(zhì)。該蛋白屬于G蛋白偶聯(lián)受體家族,能夠與前列腺素E2(PGE2)結(jié)合,從而參與多種生理和病理過程。PTGER4的常見別名包括EP4、EP4R、Ptger、PTGER2、PTGER4和Ptgerep4等。
PTGER4蛋白在人體內(nèi)的主要功能是作為PGE2的受體,介導(dǎo)PGE2引發(fā)的細(xì)胞信號傳導(dǎo)。研究表明,PTGER4激動劑能夠刺激胰島α和β細(xì)胞分泌胰高血糖素和胰島素,對血糖調(diào)節(jié)具有重要作用。此外,PTGER4還參與調(diào)節(jié)腎血流動力學(xué)、腸道上皮細(xì)胞轉(zhuǎn)運(yùn)、腎上腺醛固酮分泌以及子宮功能等。
PTGER4蛋白與多種疾病的發(fā)生發(fā)展密切相關(guān)。例如,研究表明PTGER4激動劑能夠促進(jìn)胰島α和β細(xì)胞分泌胰高血糖素和胰島素,對糖尿病的治療具有潛在價值。此外,PTGER4還與骨質(zhì)疏松癥、皮膚免疫應(yīng)答等疾病相關(guān)。

熱銷產(chǎn)品

PTGER4 Antibody (CSB-PA018973LA01HU)

驗證數(shù)據(jù)

CSB-PA018973LA01HU

Western Blot
Positive WB detected in: Rat liver tissue, Rat kidney tissue
All lanes: PTGER4 antibody at 3.2μg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 54 kDa
Observed band size: 54 kDa

CSB-PA018973LA01HU

Immunofluorescence staining of HepG2 cells with CSB-PA018973LA01HU at 1:133, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).

PTGER4 Antibodies

PTGER4 for Homo sapiens (Human)

PTGER4 Proteins

PTGER4 Proteins for Homo sapiens (Human)

PTGER4 Proteins for Mus musculus (Mouse)

PTGER4 Proteins for Rattus norvegicus (Rat)

PTGER4 Proteins for Oryctolagus cuniculus (Rabbit)

PTGER4 Proteins for Pan troglodytes (Chimpanzee)

PTGER4 Proteins for Bos taurus (Bovine)