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PRKN

PRKN,全名為parkin RBR E3泛素蛋白連接酶,也被稱為帕金蛋白。該蛋白是細胞內(nèi)重要的“質(zhì)檢員”,通過識別并標記異常蛋白質(zhì),引導細胞清理系統(tǒng)清除受損組分,維持細胞內(nèi)環(huán)境的穩(wěn)定。PRKN蛋白參與多個生理過程,包括細胞對氨基酸刺激的響應、神經(jīng)元死亡的負調(diào)控以及突觸傳遞的負調(diào)控。在神經(jīng)元死亡負調(diào)控的上游或內(nèi)部發(fā)揮作用,位于膜性器官的邊界膜、膜筏以及突觸后密度等細胞組件中,并與線粒體共定位。PRKN蛋白的研究對于理解帕金森病、2型糖尿病等疾病具有重要意義,其人類同源物與帕金森病、帕金森病2和卵巢癌有關(guān)。目前,針對PRKN蛋白的藥物研發(fā)尚處于早期階段,但已有研究表明,PRKN蛋白的異常可能與帕金森病的發(fā)生發(fā)展密切相關(guān)。

熱銷產(chǎn)品

Recombinant Human E3 ubiquitin-protein ligase parkin (PRKN) (CSB-BP017451HU)

驗證數(shù)據(jù)

CSB-BP017451HU

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

PRKN Recombinant Monoclonal Antibody (CSB-RA199844A0HU)

驗證數(shù)據(jù)

CSB-RA199844A0HU

Western Blot
Positive WB detected in: SH-SY5Y whole cell lysate(30μg), U-251MG whole cell lysate(30μg), Jurkat whole cell lysate(30μg), K562 whole cell lysate(30μg), HEK293 whole cell lysate(30μg), HEK293T whole cell lysate(30μg), SW620 whole cell lysate(30μg)
All lanes: Parkin antibody at 1:1000
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 52 kDa
Observed band size: 30 kDa
Exposure time: 2min

CSB-RA199844A0HU

Immunofluorescence staining of A-549 cell with CSB-RA199844A0HU at 1:50, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).

CSB-RA199844A0HU

Overlay Peak curve showing 786-O cells stained with CSB-RA199844A0HU (red line) at 1:100. The cells were fixed in 4% formaldehyde and permeated by 0.2% TritonX-100 for?10min. Then 10% normal goat serum to block non-specific protein-protein interactions followed by the antibody (1ug/1*106cells) for 45min at 4℃. The secondary antibody used was FITC-conjugated goat anti-rabbit IgG (H+L) at 1/200 dilution for 35min at 4℃.Control antibody (green line) was Rabbit IgG (1ug/1*106cells) used under the same conditions. Acquisition of >10,000 events was performed.

PRKN Antibody (CSB-PA017451LA01HU)

驗證數(shù)據(jù)

CSB-PA017451LA01HU

Western Blot
Positive WB detected in: HepG2 whole cell lysate, SH-SY5Y whole cell lysate, Jurkat whole cell lysate
All lanes: PRKN antibody at 3µg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 52, 49, 24, 31, 43, 36, 44, 47 kDa
Observed band size: 52 kDa

CSB-PA017451LA01HU

IHC image of CSB-PA017451LA01HU diluted at 1:600 and staining in paraffin-embedded human testis tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

CSB-PA017451LA01HU

IHC image of CSB-PA017451LA01HU diluted at 1:600 and staining in paraffin-embedded human adrenal gland tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

CSB-PA017451LA01HU

Immunofluorescent analysis of PC-3 cells using CSB-PA017451LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

PRKN Antibodies

PRKN for Homo sapiens (Human)

PRKN Proteins

PRKN Proteins for Homo sapiens (Human)

PRKN Proteins for Rattus norvegicus (Rat)

PRKN Proteins for Mus musculus (Mouse)

PRKN Proteins for Mus musculus(Mouse)



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