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PPIP5K1

Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 is a protein in humans that is encoded by PPIP5K1 gene. Bifunctional inositol kinase that acts in concert with the IP6K kinases IP6K1, IP6K2 and IP6K3 to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, exocytosis, insulin signaling and neutrophil activation. Phosphorylates inositol hexakisphosphate (InsP6) at positions 1 or 3 to produce PP-InsP5 which is in turn phosphorylated by IP6Ks to produce (PP)2-InsP4. Alternatively, phosphorylates at position 1 or 3 PP-InsP5, produced by IP6Ks from InsP6, to produce (PP)2-InsP4. Activated when cells are exposed to hyperosmotic stress.

PPIP5K1 Proteins

PPIP5K1 Proteins for Rattus norvegicus (Rat)

PPIP5K1 Proteins for Mus musculus (Mouse)

PPIP5K1 Proteins for Bos taurus (Bovine)

PPIP5K1 Proteins for Pongo abelii (Sumatran orangutan)

PPIP5K1 Proteins for Homo sapiens (Human)



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