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PMEL

PMEL,即前黑素體蛋白(Premelanosome Protein),它是一種在黑素細胞中表達的蛋白質(zhì),主要在人類中編碼于第12號染色體上。PMEL在黑素體的形成和功能中起著關(guān)鍵作用,它參與形成黑素體內(nèi)部的纖維狀結(jié)構(gòu),這些結(jié)構(gòu)有助于黑素的合成和分布。PMEL蛋白通過其不同的結(jié)構(gòu)域,包括信號肽、跨膜域、細胞質(zhì)域等,以及經(jīng)歷蛋白酶切割和糖基化等后翻譯修飾,來實現(xiàn)其功能。在生物學(xué)意義上,PMEL對維持皮膚和眼睛的色素沉著至關(guān)重要,同時,它在某些皮膚疾病如黑色素瘤的發(fā)生發(fā)展中可能也扮演著角色,是研究皮膚色素沉著和相關(guān)疾病的重要靶點。

熱銷產(chǎn)品

Recombinant Human Melanocyte protein PMEL (PMEL), partial

驗證數(shù)據(jù)

SDS
CSB-YP021324HU SDS

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

LC-MS
CSB-YP021324HU LC-MS-1

Based on the SEQUEST from database of Yeast host and target protein, the LC-MS/MS Analysis result of CSB-YP021324HU could indicate that this peptide derived from Yeast-expressed Homo sapiens (Human) PMEL.

LC-MS
CSB-YP021324HU LC-MS-2

Based on the SEQUEST from database of Yeast host and target protein, the LC-MS/MS Analysis result of CSB-YP021324HU could indicate that this peptide derived from Yeast-expressed Homo sapiens (Human) PMEL.

PMEL Antibody

驗證數(shù)據(jù)

WB
CSB-PA021324LA01HU WB

Western blot
All lanes: PMEL antibody at 14μg/ml + Jurkat whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 71, 61, 67 kDa
Observed band size: 71 kDa

IHC
CSB-PA021324LA01HU IHC-1

IHC image of CSB-PA021324LA01HU diluted at 1:200 and staining in paraffin-embedded human kidney tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

IHC
CSB-PA021324LA01HU IHC-2

IHC image of CSB-PA021324LA01HU diluted at 1:200 and staining in paraffin-embedded human melanoma performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.


PMEL Antibodies

PMEL for Homo sapiens (Human)

PMEL Proteins

PMEL Proteins for Homo sapiens (Human)



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