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PCSK9

PCSK9,即前蛋白轉化酶枯草桿菌蛋白酶/kexin9型,是一種肝臟合成分泌的酶,由PCSK9基因編碼。PCSK9的作用機制主要涉及調節血液中低密度脂蛋白受體(LDLR)的水平,通過與LDLR結合促進其在肝臟內降解,從而影響血液中的LDL-膽固醇水平。PCSK9對維持血脂穩態具有重要作用,其功能異常與家族性高膽固醇血癥等疾病相關。PCSK9抑制劑的開發為降低心血管疾病風險提供了新的治療策略。

熱銷產品

Recombinant Human Proprotein convertase subtilisin/kexin type 9 (PCSK9) (D374Y), Biotinylated (Active) (CSB-MP017647HU(M)-B)

驗證數據

CSB-MP017647HU(M)-B

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

CSB-MP017647HU(M)-B

Activity
Measured by its binding ability in a functional ELISA. Immobilized Anti-PCSK9 recombinant antibody (CSB-RA017647MA2HU) at 2 μg/ml can bind Human PCSK9 protein. The EC50 is 7.450-8.692 ng/mL.

CSB-MP017647HU(M)-B

Activity
Measured by its binding ability in a functional ELISA. Immobilized Human PCSK9 at 2 μg/ml on streptavidin coated plates can bind Anti-PCSK9 recombinant antibody (CSB-RA017647MA2HU) . The EC50 is 0.3792-1.157 ng/mL.

CSB-MP017647HU(M)-B

The purity of PCSK9 was greater than 95% as determined by SEC-HPLC

PCSK9 Recombinant Monoclonal Antibody (CSB-RA259644A0HU)

驗證數據

CSB-RA259644A0HU

Western Blot
Positive WB detected in: PC-3 whole cell lysate
All lanes: PCSK9 antibody at 1:2000
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 75, 21 kDa
Observed band size: 60, 75 kDa

CSB-RA259644A0HU

IHC image of CSB-RA259644A0HU diluted at 1:100 and staining in paraffin-embedded human colon cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4℃ overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB.

Human Proprotein convertase subtilisin/kexin type 9(PCSK9) ELISA kit (CSB-EL017647HU)

驗證數據

CSB-EL017647HU 標準曲線

貨號:CSB-EL017647HU

規格:96T/48T

靈敏度:0.11 ng/mL

檢測范圍:0.45 ng/mL-30 ng/mL

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

PCSK9 Antibodies

PCSK9 for Homo sapiens (Human)

PCSK9 Proteins

PCSK9 Proteins for Rattus norvegicus (Rat)

PCSK9 Proteins for Macaca mulatta (Rhesus macaque)

PCSK9 Proteins for Colobus guereza (Black-and-white colobus monkey)

PCSK9 Proteins for Lagothrix lagotricha (Common woolly monkey)

PCSK9 Proteins for Ateles geoffroyi (Black-handed spider monkey)

PCSK9 Proteins for Pan paniscus (Pygmy chimpanzee) (Bonobo)

PCSK9 Proteins for Pongo pygmaeus (Bornean orangutan)

PCSK9 Proteins for Saguinus labiatus (Red-chested mustached tamarin)

PCSK9 Proteins for Pan troglodytes (Chimpanzee)

PCSK9 Proteins for Callicebus moloch (Dusky titi monkey)

PCSK9 Proteins for Gorilla gorilla gorilla (Lowland gorilla)

PCSK9 Proteins for Callithrix jacchus (White-tufted-ear marmoset)

PCSK9 Proteins for Macaca nemestrina (Pig-tailed macaque)

PCSK9 Proteins for Saimiri boliviensis boliviensis (Bolivian squirrel monkey)

PCSK9 Proteins for Mus musculus (Mouse)

PCSK9 Proteins for Homo sapiens (Human)

PCSK9 ELISA Kit

PCSK9 ELISA Kit for Homo sapiens (Human)

PCSK9 ELISA Kit for Monkey

PCSK9 ELISA Kit for Rattus norvegicus (Rat)



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