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NRAS

NRAS,即神經(jīng)母細(xì)胞瘤RAS病毒癌基因同源物。別名N-ras、NRAS1。NRAS基因編碼一種GTP結(jié)合蛋白,在細(xì)胞信號(hào)傳導(dǎo)中起著分子開關(guān)的作用。它通過與GTP或GDP結(jié)合來循環(huán)激活和失活狀態(tài),控制細(xì)胞生長(zhǎng)、分化和凋亡。NRAS的作用機(jī)制涉及RAS/RAF/MEK/ERK信號(hào)通路的激活,該通路控制基因轉(zhuǎn)錄活動(dòng)和細(xì)胞周期,與細(xì)胞增殖相關(guān)。NRAS基因突變可導(dǎo)致蛋白持續(xù)激活,從而促進(jìn)腫瘤的發(fā)生和發(fā)展,如黑色素瘤、結(jié)直腸癌、非小細(xì)胞肺癌等。

熱銷產(chǎn)品

Recombinant Human GTPase NRas (NRAS) (CSB-EP016070HU)

驗(yàn)證數(shù)據(jù)

CSB-EP016070HU

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

NRAS Antibody (CSB-PA016070LA01HU)

驗(yàn)證數(shù)據(jù)

CSB-PA016070LA01HU

Immunohistochemistry of paraffin-embedded human brain tissue using CSB-PA016070LA01HU at dilution of 1:100

CSB-PA016070LA01HU

Immunofluorescent analysis of HepG2 cells using CSB-PA016070LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

NRAS Antibodies

NRAS for Homo sapiens (Human)

NRAS Proteins

NRAS Proteins for Cavia porcellus (Guinea pig)

NRAS Proteins for Mus musculus (Mouse)

NRAS Proteins for Homo sapiens (Human)

NRAS Proteins for Danio rerio (Zebrafish) (Brachydanio rerio)

NRAS Proteins for Sus scrofa (Pig)

NRAS Proteins for Gallus gallus (Chicken)

NRAS Proteins for Pongo abelii (Sumatran orangutan)

NRAS Proteins for Xenopus laevis (African clawed frog)

NRAS Proteins for Monodelphis domestica (Gray short-tailed opossum)