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NLRC5

NLRC5,即核苷酸結合寡聚結構域樣受體C5,是NOD樣受體(NLR)家族中的一員,主要在免疫細胞中發揮作用。它通過感知細胞內NAD+水平的變化來調節炎癥反應,特別是在NAD+耗竭時觸發PANoptosis,一種特殊的炎癥性細胞死亡過程。NLRC5的活性對于維持免疫平衡和抵御胞內病原體至關重要,其功能異常可能與感染、炎癥和自身免疫疾病相關。此外,NLRC5還參與調控MHC I類抗原的表達,影響CD8+ T細胞的免疫應答,是免疫學研究和潛在的治療靶點。

熱銷產品

NLRC5 Antibody (CSB-PA771457LA01HU)

驗證數據

CSB-PA771457LA01HU

IHC image of CSB-PA771457LA01HU diluted at 1:400 and staining in paraffin-embedded human lung tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

CSB-PA771457LA01HU

IHC image of CSB-PA771457LA01HU diluted at 1:400 and staining in paraffin-embedded human spleen tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

CSB-PA771457LA01HU

Immunofluorescence staining of Hela cells with CSB-PA771457LA01HU at 1:133, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).

NLRC5 Antibodies

NLRC5 for Homo sapiens (Human)

NLRC5 Proteins

NLRC5 Proteins for Homo sapiens (Human)