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NCOA1

Nuclear receptor coactivator 1 is a protein in humans that is encoded by NCOA1 gene. Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Involved in the coactivation of different nuclear receptors, such as for steroids (PGR, GR and ER), retinoids (RXRs), thyroid hormone (TRs) and prostanoids (PPARs). Also involved in coactivation mediated by STAT3, STAT5A, STAT5B and STAT6 transcription factors. Displays histone acetyltransferase activity toward H3 and H4; the relevance of such activity remains however unclear. Plays a central role in creating multisubunit coactivator complexes that act via remodeling of chromatin, and possibly acts by participating in both chromatin remodeling and recruitment of general transcription factors. Required with NCOA2 to control energy balance between white and brown adipose tissues.

NCOA1 Antibodies

NCOA1 for Homo sapiens (Human)

NCOA1 Proteins

NCOA1 Proteins for Mus musculus (Mouse)

NCOA1 Proteins for Homo sapiens (Human)

NCOA1 Proteins for Sus scrofa (Pig)



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