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MMP14

MMP14,即基質(zhì)金屬蛋白酶14,別名MT1-MMP。它由人類MMP14基因編碼,位于染色體12上。MMP14是一種膜型基質(zhì)金屬蛋白酶,主要在細胞表面發(fā)揮作用,通過其催化活性區(qū)含有的鋅離子結(jié)合位點,對酶催化作用的發(fā)揮至關(guān)重要。MMP14的作用機制包括激活其他MMPs(如MMP2),參與細胞外基質(zhì)的重塑,影響腫瘤的侵襲和轉(zhuǎn)移。MMP14參與組織發(fā)育、生殖、組織重塑等正常生理過程,同時在疾病過程中如關(guān)節(jié)炎、腫瘤轉(zhuǎn)移中發(fā)揮作用。MMP14的表達水平在多種腫瘤中上調(diào),與腫瘤的預后密切相關(guān),如在胰腺癌、肝癌等腫瘤中高表達與不良預后相關(guān)。此外,MMP14還參與調(diào)節(jié)免疫反應和炎癥過程。

熱銷產(chǎn)品

Recombinant Human Matrix metalloproteinase-14 (MMP14) (CSB-EP014661HU)

驗證數(shù)據(jù)

CSB-EP014661HU

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

CSB-EP014661HU

Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP014661HU could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) MMP14.

CSB-EP014661HU

Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP014661HU could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) MMP14.

MMP14 Antibody (CSB-PA014661ESR1HU)

驗證數(shù)據(jù)

CSB-PA014661ESR1HU

Immunohistochemistry of paraffin-embedded human breast cancer using CSB-PA014661ESR1HU at dilution of 1:100

CSB-PA014661ESR1HU

Immunohistochemistry of paraffin-embedded human colon tissue using CSB-PA014661ESR1HU at dilution of 1:100

MMP14 Antibodies

MMP14 for Homo sapiens (Human)

MMP14 Proteins

MMP14 Proteins for Homo sapiens (Human)

MMP14 Proteins for Mus musculus (Mouse)

MMP14 Proteins for Rattus norvegicus (Rat)

MMP14 Proteins for Pongo abelii (Sumatran orangutan)

MMP14 Proteins for Oryctolagus cuniculus (Rabbit)

MMP14 Proteins for Bos taurus (Bovine)

MMP14 Proteins for Sus scrofa (Pig)

MMP14 ELISA Kit



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