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MIB1

MIB1 is a protein in humans that is encoded by MIB1 gene. E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors. Probably mediates ubiquitination and subsequent proteasomal degradation of DAPK1, thereby antagonizing anti-apoptotic effects of DAPK1 to promote TNF-induced apoptosis (By similarity). Involved in ubiquitination of centriolar satellite CEP131, CEP290 and PCM1 proteins and hence inhibits primary cilium formation in proliferating cells. Mediates 'Lys-63'-linked polyubiquitination of TBK1, which probably participates in kinase activation.

MIB1 Antibodies

MIB1 for Homo sapiens (Human)

MIB1 Proteins

MIB1 Proteins for Homo sapiens (Human)

MIB1 Proteins for Xenopus laevis (African clawed frog)

MIB1 Proteins for Mus musculus (Mouse)

MIB1 Proteins for Danio rerio (Zebrafish) (Brachydanio rerio)

MIB1 Proteins for Drosophila melanogaster (Fruit fly)



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