LINGO1全稱為富含亮氨酸重復(fù)序列和免疫球蛋白樣結(jié)構(gòu)域蛋白1，也被稱為L(zhǎng)RR蛋白家族成員或神經(jīng)元再生抑制因子。LINGO1在神經(jīng)系統(tǒng)中具有獨(dú)特的調(diào)節(jié)功能，特別是在神經(jīng)元生長(zhǎng)和髓鞘形成過(guò)程中扮演"剎車"角色。LINGO1通過(guò)阻礙神經(jīng)突觸延伸和抑制少突膠質(zhì)細(xì)胞分化，顯著影響中樞神經(jīng)系統(tǒng)的自我修復(fù)能力。這種特性使其與帕金森病、特發(fā)性震顫等運(yùn)動(dòng)障礙類疾病產(chǎn)生關(guān)聯(lián)，部分患者的基因變異可能加劇神經(jīng)退行性病變進(jìn)程。
近年來(lái)針對(duì)LINGO1的抑制劑開(kāi)發(fā)取得突破性進(jìn)展，多款單克隆抗體藥物已進(jìn)入臨床試驗(yàn)階段。其中抗-LINGO1抗體在動(dòng)物模型中展現(xiàn)出促進(jìn)髓鞘再生的潛力，二期臨床數(shù)據(jù)顯示其對(duì)多發(fā)性硬化癥患者的神經(jīng)功能恢復(fù)具有改善趨勢(shì)。此外，小分子化合物篩選工作聚焦于阻斷其與受體間的特異性結(jié)合，為阿爾茨海默病等退行性疾病的治療開(kāi)辟了新路徑。該靶點(diǎn)的雙重調(diào)節(jié)特性使其成為神經(jīng)保護(hù)和再生醫(yī)學(xué)領(lǐng)域的熱門研究對(duì)象。

熱銷產(chǎn)品

Recombinant Human Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 (LINGO1), partial (CSB-EP839321HU)

驗(yàn)證數(shù)據(jù)

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

LINGO1 Antibody (CSB-PA839321ESR2HU)

驗(yàn)證數(shù)據(jù)

Western blot
All lanes: LINGO antibody at 3.12μg/ml
Lane 1: Mouse lung tissue
Lane 2: Jurkat whole cell lysate
Lane 3: A549 whole cell lysate
Lane 4: HL60 whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 70 kDa
Observed band size: 70 kDa

Immunohistochemistry of paraffin-embedded human brain tissue using CSB-PA839321ESR2HU at dilution of 1:100

Immunohistochemistry of paraffin-embedded human glioma using CSB-PA839321ESR2HU at dilution of 1:100