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LGALS8

LGALS8,即半乳糖凝集素8,別名Gal-8、PCTA1、PCTA-1、Po66-CBP。它是由人類LGALS8基因編碼的蛋白質(zhì),屬于半乳糖凝集素家族。半乳糖凝集素是一類能夠結(jié)合β-半乳糖苷的動物凝集素,具有保守的碳水化合物識別結(jié)構(gòu)域,涉及許多基本生物學功能,如發(fā)育、分化、細胞間粘附、細胞與基質(zhì)的相互作用、生長調(diào)節(jié)、細胞凋亡和RNA剪接。LGALS8能夠誘導腫瘤免疫抑制,通過分析動物模型和臨床數(shù)據(jù)發(fā)現(xiàn),LGALS8表達的腫瘤中,抑制性免疫細胞(如Tregs和MDSCs)擴增,而CD8+細胞減少,直接證明了LGALS8調(diào)節(jié)腫瘤免疫微環(huán)境的能力。此外,LGALS8與淋巴結(jié)轉(zhuǎn)移和免疫表型相關(guān),其表達水平與腫瘤的預后和進展有關(guān),表明它在腫瘤發(fā)展中的重要作用。

熱銷產(chǎn)品

Recombinant Human Galectin-8 (LGALS8) (Active) (CSB-EP012894HU)

驗證數(shù)據(jù)

CSB-EP012894HU

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

CSB-EP012894HU

Activity
Measured by its binding ability in a functional ELISA. Immobilized SLC31A1 at 5 μg/ml can bind human LGALS8, the EC50 of human LGALS8 is 373.90-524.30 μg/ml.

LGALS8 Antibody (CSB-PA012894ESR2HU)

驗證數(shù)據(jù)

CSB-PA012894ESR2HU

Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA012894ESR2HU at dilution of 1:100

CSB-PA012894ESR2HU

Immunohistochemistry of paraffin-embedded human prostate cancer using CSB-PA012894ESR2HU at dilution of 1:100

LGALS8 Antibodies

LGALS8 for Homo sapiens (Human)

LGALS8 Proteins

LGALS8 Proteins for Homo sapiens (Human)

LGALS8 ELISA Kit

LGALS8 ELISA Kit for Homo sapiens (Human)