在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

LATS2

Serine/threonine-protein kinase LATS2 is a protein in humans that is encoded by LATS2 gene. Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Acts as a tumor suppressor which plays a critical role in centrosome duplication, maintenance of mitotic fidelity and genomic stability. Negatively regulates G1/S transition by down-regulating cyclin E/CDK2 kinase activity. Negative regulator of the androgen receptor. Phosphorylates SNAI1 in the nucleus leading to its nuclear retention and stabilization, which enhances its epithelial-mesenchymal transition and tumor cell invasion/migration activities. This tumor-promoting activity is independent of its effects upon YAP1 or WWTR1/TAZ.

LATS2 Antibodies

LATS2 for Homo sapiens (Human)

LATS2 Proteins

LATS2 Proteins for Mus musculus (Mouse)

LATS2 Proteins for Homo sapiens (Human)



主站蜘蛛池模板: 久久亚洲一区二区三区四区| 国产av无码专区亚汌a√| 中文字幕欧美亚州视频免费| 中文字幕亚洲情99在线| 日本乱人伦在线观看| 男女裸体下面进入的免费视频| 亚洲性无码av在线| 久久亚洲欧美国产精品| 人妻av中文字幕无码专区| 成人片黄网站a毛片免费| 99在线精品一区二区三区| 国产av亚洲精品ai换脸电影| 欧美肥老太牲交大战| 精品久久人人爽天天玩人人妻| 精品国产乱码久久久久软件| 国产破外女出血视频| 亚洲国产欧美中文丝袜日韩| 国产热の有码热の无码视频| 人妻中文字幕乱人伦在线| 国产爆乳无码视频在线观看| 插插插精品亚洲一区| 97久久精品人人做人人爽| 西西人体www大胆高清| 综合久久国产九一剧情麻豆 | av无码久久久精品免费| 米奇7777狠狠狠狠视频影院| 国产日产亚洲系列最新| 人人妻人人爽人人澡欧美一区| 国产精品久久国产精麻豆99网站| 亚洲国产成人无码av在线| 老熟女毛茸茸浓毛| 久久久久久无码日韩欧美| 丰满少妇被猛烈进入试看| 超碰人人超碰人人| 色婷婷综合和线在线| 天天躁夜夜躁狠狠综合| 久久久精品免费| 日本丰满少妇xxxx| 亚洲精品国产自在现线看| 双乳奶水饱满少妇呻吟| 成人午夜视频精品一区|