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KLRB1

KLRB1,全稱(chēng)“殺傷細(xì)胞凝集素樣受體亞家族B成員1”,別名CD161,是一種II型膜蛋白,主要表達(dá)于自然殺傷(NK)細(xì)胞和部分T細(xì)胞表面。CD161蛋白具有C型凝集素特征的結(jié)構(gòu)域,參與調(diào)節(jié)NK細(xì)胞和T細(xì)胞的免疫功能。在NK細(xì)胞中,CD161與其配體LLT1結(jié)合,抑制細(xì)胞毒性并調(diào)節(jié)細(xì)胞因子分泌。而在T細(xì)胞中,CD161可作為激活型受體,參與Th17細(xì)胞的分化和IL-17的分泌。CD161的表達(dá)受IL-12等細(xì)胞因子調(diào)控,并在免疫應(yīng)答中發(fā)揮重要作用。相關(guān)研究表明,CD161在腫瘤微環(huán)境中可作為治療靶點(diǎn),通過(guò)阻斷CD161-LLT1結(jié)合增強(qiáng)NK細(xì)胞活性,或激活T細(xì)胞殺傷腫瘤細(xì)胞。目前,針對(duì)CD161的抗體和免疫檢查點(diǎn)抑制劑等藥物研發(fā)正在進(jìn)行中,有望為腫瘤治療提供新策略。

熱銷(xiāo)產(chǎn)品

KLRB1 Antibody (CSB-PA249906)

驗(yàn)證數(shù)據(jù)

CSB-PA249906

The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA249906(KLRB1 Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: ×200)

CSB-PA249906

The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using CSB-PA249906(KLRB1 Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: ×200)

CSB-PA249906

Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane 1-2: Mouse kidney tissue, human fetal liver tissue, Primary antibody: CSB-PA249906(KLRB1 Antibody) at dilution 1/300, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute

KLRB1 Antibodies

KLRB1 for Homo sapiens (Human)

KLRB1 Proteins

KLRB1 Proteins for Homo sapiens (Human)