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KLK1

KLK1全稱為激肽釋放酶1,又稱組織激肽釋放酶或hK1,是絲氨酸蛋白酶家族成員。該蛋白在人體多個組織表達,能夠水解低分子量激肽原生成活性激肽,參與調節血壓、電解質平衡及炎癥反應過程。KLK1與緩激肽系統存在密切關聯,在血管舒張、細胞增殖等生理活動中扮演關鍵角色。
KLK1異常表達與高血壓、慢性腎病及動脈粥樣硬化等疾病相關,尤其在糖尿病腎病患者的尿液中常檢測到濃度升高。近年來,基于其調節血壓的特性,科研團隊嘗試開發重組激肽釋放酶1作為治療缺血性中風和心肌梗死的候選藥物。同時,針對其抑制劑的研究也在推進中,用于緩解激肽過度釋放引發的炎癥反應。目前已有部分小分子化合物進入臨床前研究階段,但成藥性仍需進一步驗證。

熱銷產品

Recombinant Human Kallikrein-1 (KLK1) (CSB-EP012446HU)

驗證數據

CSB-EP012446HU

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

KLK1 Antibody (CSB-PA012446LA01HU)

驗證數據

CSB-PA012446LA01HU

IHC image of CSB-PA012446LA01HU diluted at 1:300 and staining in paraffin-embedded human breast cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

CSB-PA012446LA01HU

IHC image of CSB-PA012446LA01HU diluted at 1:300 and staining in paraffin-embedded human kidney tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

CSB-PA012446LA01HU

Immunofluorescence staining of Hela cells with CSB-PA012446LA01HU at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).

Human Kallikrein 1,KLK 1 ELISA Kit (CSB-E11437h)

驗證數據

CSB-E11437h 標準曲線

貨號:CSB-E11437h

規格:96T/48T

靈敏度:0.195 ng/mL

檢測范圍:0.78 ng/mL-50 ng/mL

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

KLK1 Antibodies

KLK1 for Homo sapiens (Human)

KLK1 Proteins

KLK1 Proteins for Mus musculus (Mouse)

KLK1 Proteins for Homo sapiens (Human)

KLK1 Proteins for Papio hamadryas (Hamadryas baboon)

KLK1 Proteins for Blarina brevicauda (Short-tailed shrew)

KLK1 ELISA Kit

KLK1 ELISA Kit for Homo sapiens (Human)