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ITPRIPL1

ITPRIPL1,全稱為Inositol 1,4,5-Triphosphate Receptor Interacting Protein-Like 1,常見別名包括ITPRIP like 1、inositol 1,4,5-trisphosphate receptor interacting protein-like 1等。該蛋白參與調(diào)節(jié)內(nèi)質(zhì)網(wǎng)中的鈣釋放,其表達(dá)與多種疾病相關(guān),如脊髓小腦共濟(jì)失調(diào)15型等。研究表明,ITPRIPL1作為CD3ε的抑制配體,能夠抑制T細(xì)胞的活化,從而促進(jìn)腫瘤的免疫逃逸。這一發(fā)現(xiàn)為腫瘤免疫治療提供了新的靶點(diǎn),相關(guān)抗體已進(jìn)入臨床研究階段。此外,ITPRIPL1的表達(dá)也可能與睪丸免疫豁免有關(guān),其在睪丸中的高表達(dá)有助于維持免疫系統(tǒng)的平衡。目前,針對(duì)ITPRIPL1的藥物研發(fā)正在積極進(jìn)行中,有望為腫瘤治療和免疫調(diào)節(jié)領(lǐng)域帶來新的突破。

熱銷產(chǎn)品

Recombinant Human Inositol 1,4,5-trisphosphate receptor-interacting protein-like 1 (ITPRIPL1), partial (Active) (CSB-MP756966HU)

驗(yàn)證數(shù)據(jù)

CSB-MP756966HU

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

CSB-MP756966HU

Activity
Measured by its binding ability in a functional ELISA. Immobilized Human ITPRIPL1 at 2 μg/ml can bind Anti-ITPRIPL1 recombinant antibody (CSB-RA756966MA1HU). The EC50 is 6.537-7.663 ng/mL.

ITPRIPL1 Recombinant Monoclonal Antibody (CSB-RA756966MA1HU)

驗(yàn)證數(shù)據(jù)

CSB-RA756966MA1HU

The Binding Activity of Macaca fascicularis ITPRIPL1 with Anti-ITPRIPL1 recombinant antibody
Activity: Measured by its binding ability in a functional ELISA. Immobilized Macaca fascicularis ITPRIPL1 (CSB-MP6125MOV) at 2 μg/mL can bind Anti-ITPRIPL1 recombinant antibody. The EC50 is 3.759-4.428 ng/mL.

CSB-RA756966MA1HU

The Binding Activity of Human ITPRIPL1 with Anti-ITPRIPL1 recombinant antibody
Activity: Measured by its binding ability in a functional ELISA. Immobilized Human ITPRIPL1 (CSB-MP756966HU) at 2 μg/mL can bind Anti-ITPRIPL1 recombinant antibody. The EC50 is 6.537-7.663 ng/mL.

CSB-RA756966MA1HU

The Binding Activity of Mouse Itpripl1 with Anti-ITPRIPL1 Recombinant Antibody
Activity: Measured by its binding ability in a functional ELISA. Immobilized Mouse Itpripl1 (CSB-MP011916MO1) at 2 μg/mL can bind Anti-ITPRIPL1 recombinant antibody. The EC50 is 0.7534-0.9877 ng/mL.

ITPRIPL1 Antibodies

ITPRIPL1 for Homo sapiens (Human)

ITPRIPL1 Proteins

ITPRIPL1 Proteins for Homo sapiens (Human)



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