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ISL1

Insulin gene enhancer protein ISL-1 is a protein in humans that is encoded by ISL1 gene. DNA-binding transcriptional activator. Recognizes and binds to the consensus octamer binding site 5'-ATAATTAA-3' in promoter of target genes. Plays a fundamental role in the gene regulatory network essential for retinal ganglion cell (RGC) differentiation. Cooperates with the transcription factor POU4F2 to achieve maximal levels of expression of RGC target genes and RGC fate specification in the developing retina. Involved in the specification of motor neurons in cooperation with LHX3 and LDB1. Binds to insulin gene enhancer sequences. Essential for heart development. Marker of one progenitor cell population that give rise to the outflow tract, right ventricle, a subset of left ventricular cells, and a large number of atrial cells as well, its function is required for these progenitors to contribute to the heart.

ISL1 Antibodies

ISL1 for Homo sapiens (Human)

ISL1 for Danio rerio (Zebrafish) (Brachydanio rerio)

ISL1 Proteins

ISL1 Proteins for Gallus gallus (Chicken)

ISL1 Proteins for Rattus norvegicus (Rat)

ISL1 Proteins for Homo sapiens (Human)

ISL1 Proteins for Mus musculus (Mouse)

ISL1 Proteins for Danio rerio (Zebrafish) (Brachydanio rerio)

ISL1 Proteins for Mesocricetus auratus (Golden hamster)



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