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INSR

INSR,即胰島素受體(Insulinreceptor),別名IGFR、IRR。INSR由人類INSR基因編碼,該基因位于19號染色體的p13.2區(qū)域。INSR是一種跨膜受體酪氨酸激酶,屬于受體酪氨酸激酶家族的Ⅱ型亞家族。當胰島素與其受體結合后,通過一系列結構構象變化,激活胞內(nèi)酪氨酸激酶活性,起始胞內(nèi)信號傳導。
INSR在調(diào)節(jié)血糖水平中發(fā)揮關鍵作用,促進葡萄糖進入肝細胞、肌細胞、脂肪細胞及其他組織細胞合成糖原,降低血糖,并促進脂肪及蛋白質(zhì)的合成。INSR的異常可能導致多種代謝性疾病,包括糖尿病和胰島素抵抗。

熱銷產(chǎn)品

Recombinant Human Insulin receptor (INSR),Partial (CSB-EP011753HU)

驗證數(shù)據(jù)

CSB-EP011753HU

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

INSR Antibody (CSB-PA011753LA01HU)

驗證數(shù)據(jù)

CSB-PA011753LA01HU

Immunohistochemistry of paraffin-embedded human liver cancer using CSB-PA011753LA01HU at dilution of 1:100

CSB-PA011753LA01HU

Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA011753LA01HU at dilution of 1:100

CSB-PA011753LA01HU

Immunofluorescent analysis of HepG2 cells using CSB-PA011753LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

INSR Antibodies

INSR for Homo sapiens (Human)

INSR Proteins

INSR Proteins for Mus musculus (Mouse)

INSR Proteins for Rattus norvegicus (Rat)

INSR Proteins for Homo sapiens (Human)

INSR Proteins for Xenopus laevis (African clawed frog)

INSR Proteins for Macaca mulatta (Rhesus macaque)