ILDR2
ILDR2蛋白全稱為免疫球蛋白樣結構域受體2,也被稱為IMD2或LISCH樣蛋白,其分子結構中含有典型的免疫球蛋白功能域,主要分布于上皮細胞表面。該蛋白在維持細胞極性及細胞間連接中發揮關鍵作用,尤其與內耳毛細胞、肝臟及乳腺等組織的發育密切相關。ILDR2功能異??赡芤l先天性耳聾、膽管閉鎖及部分乳腺癌的發生,例如某些病例中ILDR2基因突變導致聽覺神經信號傳遞受阻,進而引發非綜合征型聽力損傷。
近年來,ILDR2與代謝調控的關聯逐漸被揭示。在糖尿病研究中,ILDR2通過影響胰島素分泌細胞的完整性,可能參與血糖平衡調節。此外,針對ILDR2的藥物開發尚處于早期階段,但其在腫瘤微環境中的特殊表達模式已引起關注,部分抗體藥物偶聯物(ADC)研究將其作為潛在靶點。ILDR2與緊密連接蛋白家族的功能協同性,為治療上皮屏障相關疾病提供了新思路,例如炎癥性腸病的干預策略探索。
熱銷產品
Recombinant Human Immunoglobulin-like domain-containing receptor 2 (ILDR2), partial (CSB-EP751251HU)
驗證數據

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
ILDR2 Recombinant Monoclonal Antibody (CSB-RA751251MA1HU)
驗證數據

Immunofluorescence?staining?of?Hela?cell?with?CSB-RA751251MA1HU?at?1:30,?counter-stained?with?DAPI.?The?cells?were?fixed?in?4%?formaldehyde?and?blocked?in?10%?normal?Goat?Serum.?The?cells?were?then?incubated?with?the?antibody?overnight?at?4C.?The?secondary?antibody?was?FITC-conjugated?AffiniPure?Goat?Anti-Human?IgG(H+L).

Immunofluorescence?staining?of U251?cell?with?CSB-RA751251MA1HU?at?1:30,?counter-stained?with?DAPI.?The?cells?were?fixed?in?4%?formaldehyde?and?blocked?in?10%?normal?Goat?Serum.?The?cells?were?then?incubated?with?the?antibody?overnight?at?4C.?The?secondary?antibody?was?FITC-conjugated?AffiniPure?Goat?Anti-Human?IgG(H+L).

Overlay Peak curve showing Jurkat cells stained with CSB-RA751251MA1HU (red line) at 1:100. The cells were fixed in 4% formaldehyde and permeated by 0.2% TritonX-100.Then 10% normal goat serum to block non-specific protein-protein interactions followed by the antibody (1ug/1*106cells) for 45min at 4℃. The secondary antibody used was FITC-conjugated Goat Anti-human IgG(H+L) at 1:200 dilution for 35min at 4℃.Control antibody (green line) was human IgG (1ug/1*106cells) used under the same conditions. Acquisition of >10,000 events was performed.
ILDR2 Antibodies
ILDR2 for Homo sapiens (Human)
產品貨號 | 產品名稱 | 種屬反應性 | 應用類型 |
---|---|---|---|
CSB-RA751251MA1HU | ILDR2 Recombinant Monoclonal Antibody | Human | ELISA, IF, FC |
ILDR2 Proteins
ILDR2 Proteins for Homo sapiens (Human)
產品貨號 | 產品名稱 | 來源 |
---|---|---|
CSB-YP751251HU | Recombinant Human Immunoglobulin-like domain-containing receptor 2 (ILDR2), partial | Yeast |
CSB-EP751251HU | Recombinant Human Immunoglobulin-like domain-containing receptor 2 (ILDR2), partial | E.coli |
CSB-BP751251HU CSB-MP751251HU CSB-EP751251HU-B |
Recombinant Human Immunoglobulin-like domain-containing receptor 2 (ILDR2), partial | Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |