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IL1A

IL1A,即白細(xì)胞介素1α,別名IL-1α、Hematopoietin-1、Lymphocyte-Activating Factor (LAF)、Endogenous Pyrogen (EP)、IL1F1等。它是一種由IL1A基因編碼的多效性細(xì)胞因子,主要由活化的巨噬細(xì)胞、中性粒細(xì)胞、上皮細(xì)胞和內(nèi)皮細(xì)胞產(chǎn)生 。IL1A的作用機(jī)制涉及其前體蛋白在細(xì)胞內(nèi)的轉(zhuǎn)錄因子功能以及成熟形式在細(xì)胞外的信號(hào)傳導(dǎo)作用。IL1A前體在細(xì)胞核內(nèi)促進(jìn)基因表達(dá),調(diào)控細(xì)胞生長(zhǎng)和分化。成熟形式的IL1A通過與細(xì)胞表面的IL-1受體IL1R1結(jié)合,觸發(fā)信號(hào)傳導(dǎo)復(fù)合物的形成,激活NF-kappa-B和MAPK通路,從而引發(fā)炎癥反應(yīng)和免疫應(yīng)答 。在生物學(xué)意義上,IL1A在機(jī)體的炎癥反應(yīng)、免疫調(diào)節(jié)以及與多種疾病的關(guān)聯(lián)中發(fā)揮關(guān)鍵作用。它參與機(jī)體抗微生物感染、無菌炎癥、腫瘤相關(guān)疾病以及自發(fā)炎癥的調(diào)節(jié)。IL1A的異常表達(dá)與多種疾病有關(guān),包括Fabry病、Schnitzler綜合征、多種自身免疫性疾病、血液腫瘤和肺部疾病等。因此,IL1A是炎癥和免疫相關(guān)疾病研究中的一個(gè)重要分子靶點(diǎn),并且是臨床治療多種疾病的潛在標(biāo)志物和治療靶點(diǎn) 。

熱銷產(chǎn)品

Recombinant Human Interleukin-1 alpha (IL1A) (CSB-YP011613HU)

驗(yàn)證數(shù)據(jù)

CSB-YP011613HU

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

IL1A Antibody (CSB-PA584603)

驗(yàn)證數(shù)據(jù)

CSB-PA584603

The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using CSB-PA584603(IL1A Antibody) at dilution 1/60, on the right is treated with fusion protein. (Original magnification: ×200)

CSB-PA584603

The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA584603(IL1A Antibody) at dilution 1/60, on the right is treated with fusion protein. (Original magnification: ×200)

CSB-PA584603

Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: Jurkat cells, Primary antibody: CSB-PA584603(IL1A Antibody) at dilution 1/666, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 20 seconds

Human Interleukin 1α,IL-1α ELISA Kit (CSB-E04620h)

驗(yàn)證數(shù)據(jù)

CSB-E04620h 標(biāo)準(zhǔn)曲線

貨號(hào):CSB-E04620h

規(guī)格:96T/48T

靈敏度:0.975 pg/ml.

檢測(cè)范圍:3.9 pg/ml-250 pg/ml.

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

IL1A Antibodies

IL1A for Homo sapiens (Human)

IL1A for Macaca mulatta

IL1A Proteins

IL1A Proteins for Capra hircus (Goat)

IL1A Proteins for Sus scrofa (Pig)

IL1A Proteins for Macaca mulatta (Rhesus macaque)

IL1A Proteins for Mus musculus (Mouse)

IL1A Proteins for Homo sapiens (Human)

IL1A Proteins for Bos taurus (Bovine)

IL1A Proteins for Oryctolagus cuniculus (Rabbit)

IL1A Proteins for Felis catus (Cat) (Felis silvestris catus)

IL1A Proteins for Canis familiaris (Dog) (Canis lupus familiaris)

IL1A Proteins for Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)

IL1A Proteins for Rattus norvegicus (Rat)

IL1A Proteins for Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys)

IL1A Proteins for Ovis aries (Sheep)

IL1A Proteins for Equus caballus (Horse)

IL1A Proteins for Bubalus carabanensis (Swamp type water buffalo) (Bubalus bubalis carabanensis)

IL1A Proteins for Cavia porcellus (Guinea pig)

IL1A Proteins for Lama glama (Llama)

IL1A ELISA Kit

IL1A ELISA Kit for Bos taurus (Bovine)

IL1A ELISA Kit for Oryctolagus cuniculus (Rabbit)

IL1A ELISA Kit for Homo sapiens (Human)

IL1A ELISA Kit for Mus musculus (Mouse)

IL1A ELISA Kit for Sus scrofa (Pig)

IL1A ELISA Kit for Rattus norvegicus (Rat)

IL1A ELISA Kit for Monkey



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