IGSF9
IGSF9,全稱為免疫球蛋白超家族成員9,是一種廣泛存在于細(xì)胞膜上的蛋白質(zhì),其特點(diǎn)在于含有免疫球蛋白樣結(jié)構(gòu)域,參與細(xì)胞間的識(shí)別、黏附和信號(hào)傳導(dǎo)等過程。IGSF9蛋白在突觸部位富集,作為一種跨膜蛋白,與其他突觸蛋白相互作用,參與突觸的形成和功能調(diào)控。研究表明,IGSF9蛋白在抑制性突觸中發(fā)揮重要作用,通過與突觸后支架蛋白如Gephyrin結(jié)合,調(diào)節(jié)GABA能突觸的穩(wěn)定性和功能,從而影響神經(jīng)回路的興奮與抑制平衡。
IGSF9蛋白的突變或表達(dá)異常可能導(dǎo)致突觸功能紊亂,與多種神經(jīng)系統(tǒng)疾病相關(guān),如自閉癥譜系障礙、精神分裂癥和癲癇等。動(dòng)物模型中發(fā)現(xiàn),IGSF9蛋白的缺失會(huì)導(dǎo)致小鼠表現(xiàn)出社交行為異常和焦慮樣行為增加,提示其與神經(jīng)精神疾病密切相關(guān)。IGSF9蛋白的過表達(dá)可能增強(qiáng)抑制性突觸的功能,導(dǎo)致神經(jīng)回路過度抑制,而表達(dá)降低則可能削弱抑制性突觸,引發(fā)神經(jīng)興奮性增高。此外,IGSF9蛋白還可能與其它IgSF成員如SynCAM家族存在功能交叉,共同調(diào)控突觸可塑性。IGSF9蛋白的研究有助于深入理解突觸調(diào)控機(jī)制及相關(guān)疾病的病理基礎(chǔ),為相關(guān)疾病的治療提供新的思路。
熱銷產(chǎn)品
Recombinant Human Protein turtle homolog A (IGSF9), partial (CSB-MP882181HUd7)
驗(yàn)證數(shù)據(jù)

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

The purity of IGSF9 was greater than 95% as determined by SEC-HPLC
IGSF9 Antibody (CSB-PA23039A0Rb)
驗(yàn)證數(shù)據(jù)

IHC image of CSB-PA23039A0Rb diluted at 1:200 and staining in paraffin-embedded human endometrial cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

IHC image of CSB-PA23039A0Rb diluted at 1:200 and staining in paraffin-embedded human prostate cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
IGSF9 Antibodies
IGSF9 for Homo sapiens (Human)
產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
---|---|---|---|
CSB-PA23039A0Rb | IGSF9 Antibody | Human | ELISA, IHC |
CSB-PA23039B0Rb | IGSF9 Antibody, HRP conjugated | Human | ELISA |
CSB-PA23039C0Rb | IGSF9 Antibody, FITC conjugated | Human | |
CSB-PA23039D0Rb | IGSF9 Antibody, Biotin conjugated | Human | ELISA |
IGSF9 Proteins
IGSF9 Proteins for Homo sapiens (Human)
產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
---|---|---|
CSB-YP882181HU CSB-BP882181HU CSB-EP882181HU-B |
Recombinant Human Protein turtle homolog A (IGSF9), partial | Yeast Baculovirus In Vivo Biotinylation in E.coli |
CSB-EP882181HU | Recombinant Human Protein turtle homolog A (IGSF9), partial | E.coli |
CSB-MP882181HUd7 | Recombinant Human Protein turtle homolog A (IGSF9), partial | Mammalian cell |
CSB-MP882181HU | Recombinant Human Protein turtle homolog A(IGSF9), partial | Mammalian cell |