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ICAM1

ICAM1,即細胞間黏附分子1,別名包括CD54。它是一種由ICAM1基因編碼的細胞表面糖蛋白,通常在內皮細胞和免疫系統的細胞上表達。ICAM1的作用機制涉及與白細胞相關抗原1(LFA-1)和巨噬細胞1(Mac-1)等整合素家族成員的相互作用,這些整合素是ICAM-1的主要受體。ICAM1在多種生物學過程中發揮作用,包括細胞黏附、信號轉導、免疫應答、炎癥反應、細胞增殖、分化、遷移和凋亡等。ICAM1參與了多種生理和病理過程的調節。ICAM1的表達在炎癥反應中增加,促進白細胞與內皮細胞的黏附,有助于白細胞穿越血管壁進入炎癥部位。此外,ICAM1在控制腫瘤惡化和轉移以及調節機體免疫反應中也起重要作用。ICAM1通過與其受體的特異性結合,增強白細胞、炎癥細胞和腫瘤細胞等與內皮細胞間的黏附作用,促進內皮細胞活化,使它們更容易穿透內皮。ICAM1還參與細胞的信號轉導與活化、細胞組織生長及分化、血管生成及腫瘤轉移等生理病理過程 。

熱銷產品

Recombinant Human Intercellular adhesion molecule 1 (ICAM1), partial (CSB-EP010949HU)

驗證數據

CSB-EP010949HU

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

ICAM1 Recombinant Monoclonal Antibody (CSB-RA162789A0HU)

驗證數據

CSB-RA162789A0HU

IHC image of CSB-RA162789A0HU diluted at 1:100 and staining in paraffin-embedded human tonsil tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4℃ overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB.

CSB-RA162789A0HU

IHC image of CSB-RA162789A0HU diluted at 1:100 and staining in paraffin-embedded human lung cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4℃ overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB.

CSB-RA162789A0HU

Overlay histogram showing Raji cells surface stained with CSB-RA162789A0HU (red line) at 1:50. The cells were incubated in 10% normal goat serum to block non-specific protein-protein interactions followedby the antibody (1μg/1*106 cells) for 1 h at 4℃.The secondary antibody used was FITC-conjugated goat anti-rabbit IgG (H+L) at 1/200 dilution for 30min at 4℃. Control antibody (green line) was Rabbit IgG (1μg/1*106 cells) used under the same conditions. Acquisition of >10,000 events was performed.

ICAM1 Antibodies

ICAM1 for Homo sapiens (Human)

ICAM1 Proteins

ICAM1 Proteins for Rattus norvegicus (Rat)

ICAM1 Proteins for Mus musculus (Mouse)

ICAM1 Proteins for Canis familiaris (Dog) (Canis lupus familiaris)

ICAM1 Proteins for Homo sapiens (Human)

ICAM1 Proteins for Pan paniscus (Pygmy chimpanzee) (Bonobo)

ICAM1 Proteins for Bos taurus (Bovine)

ICAM1 Proteins for Pan troglodytes (Chimpanzee)

ICAM1 Proteins for Gorilla gorilla gorilla (Lowland gorilla)

ICAM1 Proteins for Macaca mulatta (Rhesus macaque)

ICAM1 ELISA Kit

ICAM1 ELISA Kit for Canis lupus familiaris (Dog) (Canis familiaris)

ICAM1 ELISA Kit for Homo sapiens (Human)

ICAM1 ELISA Kit for Mus musculus (Mouse)

ICAM1 ELISA Kit for Rattus norvegicus (Rat)