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HSF1

HSF1,即熱休克轉(zhuǎn)錄因子1,也稱為HSTF1,是一種轉(zhuǎn)錄因子,在溫度脅迫后被迅速誘導,能夠結合熱休克啟動子元件(HSE)。這種蛋白質(zhì)在調(diào)節(jié)壽命方面發(fā)揮作用,其表達受到磷酸化的抑制,磷酸化促進熱休克蛋白90的結合。HSF1是細胞熱休克蛋白(HSP)表達的主要調(diào)控因子,在不同物種中高度保守。
HSF1在應激反應中能啟動基因的轉(zhuǎn)錄過程,促進HSPs的表達,發(fā)揮耐受不良刺激、保持細胞完整性、減輕炎癥和參與免疫等重要適應性保護作用。
HSF1還能直接或間接調(diào)節(jié)許多非熱休克基因的表達,在正常的發(fā)育過程或病理事件中具有不依賴熱休克或其他細胞應激的重要功能。

熱銷產(chǎn)品

HSF1 Recombinant Monoclonal Antibody (CSB-RA279005A0HU)

驗證數(shù)據(jù)

CSB-RA279005A0HU

IHC image of CSB-RA279005A0HU diluted at 1:100 and staining in paraffin-embedded human ovarian cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4℃ overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB.

CSB-RA279005A0HU

IHC image of CSB-RA279005A0HU diluted at 1:100 and staining in paraffin-embedded human testis tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4℃ overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB.

HSF1 Antibodies

HSF1 for Homo sapiens (Human)