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H2AFX

Histone H2AX is a protein in humans that is encoded by H2AFX gene. Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Required for checkpoint-mediated arrest of cell cycle progression in response to low doses of ionizing radiation and for efficient repair of DNA double strand breaks (DSBs) specifically when modified by C-terminal phosphorylation.

H2AFX Antibodies

H2AFX for Homo sapiens (Human)

H2AFX Proteins

H2AFX Proteins for Homo sapiens (Human)

H2AFX Proteins for Mus musculus (Mouse)

H2AFX Proteins for Xenopus laevis (African clawed frog)

H2AFX Proteins for Danio rerio (Zebrafish) (Brachydanio rerio)



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