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GCGR

GCGR,全稱是胰高血糖素受體(Glucagon Receptor),別名包括Glucagon R、GCGR、Glucagon Receptor、GGR等。該蛋白主要分布在肝臟、腎臟、脂肪組織、心臟和胰腺等部位,在調節血糖水平方面發揮著關鍵作用。胰高血糖素可以直接作用于肝臟,促進糖原分解,提高血糖水平,同時還能促進脂肪分解和能量消耗。GCGR受體是糖尿病和肥胖治療的重要靶點,目前已有多種針對GCGR的藥物進入臨床研發階段,包括激動劑和拮抗劑等。其中,GCGR/GLP-1R雙激動劑和GCGR/GIPR/GLP-1R三重激動劑在肥胖和2型糖尿病治療中展現出良好的效果。

熱銷產品

Recombinant Human Glucagon receptor (GCGR), partial (Active) (CSB-MP009316HU1)

驗證數據

CSB-MP009316HU1

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

CSB-MP009316HU1

Activity
Measured by its binding ability in a functional ELISA. Immobilized human GCGR at 2 μg/ml can bind Anti-GCGR recombinant antibody (CSB-RA009316A1HU), the EC50 is 3.747-6.666 ng/mL.

GCGR Recombinant Monoclonal Antibody (CSB-RA009316A1HU)

驗證數據

CSB-RA009316A1HU

The Binding Activity of Human GCGR with Anti-GCGR recombinant antibody.
Activity: Measured by its binding ability in a functional ELISA. Immobilized Human GCGR (CSB-MP009316HU1) at 2 μg/mL can bind Anti-GCGR recombinant antibody, the EC50 is 14.57-32.56 ng/mL.

CSB-RA009316A1HU

The Binding Activity of Human GCGR with Anti-GCGR recombinant antibody.
Activity: Measured by its binding ability in a functional ELISA. Immobilized Human GCGR (CSB-YP009316HU1) at 2 μg/mL can bind Anti-GCGR recombinant antibody, the EC50 is 104.1-179.5 ng/mL.

GCGR Antibodies

GCGR for Homo sapiens (Human)

GCGR Proteins

GCGR Proteins for Rattus norvegicus (Rat)

GCGR Proteins for Homo sapiens (Human)

GCGR Proteins for Mus musculus (Mouse)