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G3BP1

G3BP1 is a protein in humans that is encoded by G3BP1 gene. ATP- and magnesium-dependent helicase that plays an essential role in innate immunity. Participates in the DNA-triggered cGAS/STING pathway by promoting the DNA binding and activation of CGAS. Enhances also DDX58-induced type I interferon production probably by helping DDX58 at sensing pathogenic RNA. In addition, plays an essential role in stress granule formation. Unwinds preferentially partial DNA and RNA duplexes having a 17 bp annealed portion and either a hanging 3' tail or hanging tails at both 5'- and 3'-ends. Unwinds DNA/DNA, RNA/DNA, and RNA/RNA substrates with comparable efficiency. Acts unidirectionally by moving in the 5' to 3' direction along the bound single-stranded DNA. Phosphorylation-dependent sequence-specific endoribonuclease in vitro. Cleaves exclusively between cytosine and adenine and cleaves MYC mRNA preferentially at the 3'-UTR.

G3BP1 Antibodies

G3BP1 for Homo sapiens (Human)

G3BP1 Proteins

G3BP1 Proteins for Mus musculus (Mouse)

G3BP1 Proteins for Homo sapiens (Human)

G3BP1 Proteins for Bos taurus (Bovine)

G3BP1 Proteins for Pongo abelii (Sumatran orangutan)



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