FLRT3
纖連蛋白富亮氨酸跨膜蛋白3(FLRT3),又稱HH21或KIAA1469,是一種廣泛表達于腎臟、大腦、肺等組織的跨膜蛋白,其分子結構包含纖連蛋白III型結構域和多個亮氨酸重復序列,通過介導細胞間粘附與遷移參與多種生理過程。在神經系統中,FLRT3通過結合Unc5B等受體調控軸突引導和突觸形成,影響神經元空間組織與視網膜血管發育;在胚胎發育中,它對腹側閉合和內胚層遷移等形態發生過程至關重要。
FLRT3功能異常與多種疾病密切相關。神經性疼痛模型顯示,脊髓背角FLRT3表達升高會通過Unc5B受體增強神經興奮性,加劇疼痛敏感性,而抑制其活性可顯著緩解痛覺過敏。在癌癥領域,FLRT3與UNC5B形成的軸突引導信號軸被證實可抑制T細胞活性,促進腎癌、膀胱癌等腫瘤免疫逃逸,靶向該通路的單克隆抗體NP591已進入臨床前研究,展現出增強PD-1藥物療效的潛力。此外,FLRT3通過調控RND3-RhoA通路影響肺血管內皮屏障功能,可能成為肺缺血再灌注損傷治療的新靶點。目前針對FLRT3的診斷試劑盒和抗體藥物正在開發中,其作為疾病標志物和治療靶點的價值正逐步顯現。
熱銷產品
FLRT3 Antibody (CSB-PA882162LA01HU)
驗證數據

Western blot
All lanes: DARS2 antibody at 16μg/ml
Lane 1: Mouse heart tissue
Lane 2: Mouse liver tissue
Lane 3: Mouse brain tissue
Lane 4: Mouse skeletal muscle tissue
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 73 kDa
Observed band size: 73 kDa

Immunofluorescent analysis of HepG2 cells using CSB-PA882162LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
FLRT3 Antibodies
FLRT3 for Homo sapiens (Human)
產品貨號 | 產品名稱 | 種屬反應性 | 應用類型 |
---|---|---|---|
CSB-PA882162LA01HU | FLRT3 Antibody | Human, Mouse | ELISA, WB, IF |
CSB-PA882162LB01HU | FLRT3 Antibody, HRP conjugated | Human | ELISA |
CSB-PA882162LC01HU | FLRT3 Antibody, FITC conjugated | Human | |
CSB-PA882162LD01HU | FLRT3 Antibody, Biotin conjugated | Human | ELISA |
FLRT3 Proteins
FLRT3 Proteins for Homo sapiens (Human)
產品貨號 | 產品名稱 | 來源 |
---|---|---|
CSB-YP882162HU CSB-EP882162HU CSB-BP882162HU CSB-MP882162HU CSB-EP882162HU-B |
Recombinant Human Leucine-rich repeat transmembrane protein FLRT3 (FLRT3), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |