FCAR
FCAR(FcαRI),全稱為高親和力免疫球蛋白E受體I,常見別名包括CD89。該蛋白主要表達于嗜酸性粒細胞、肥大細胞和血小板等細胞上,其核心功能是介導免疫球蛋白E(IgE)與靶細胞結合,引發I型超敏反應及其他免疫應答。FCAR通過與IgE結合,激活下游信號分子,如磷脂酰肌醇3-激酶(PI3K)和蛋白激酶C(PKC),進而促進細胞脫顆粒、釋放炎癥介質和趨化因子,參與過敏反應和抗感染過程。此外,FCAR還與某些自身免疫性疾病和腫瘤的發病機制相關,例如過敏性哮喘、過敏性鼻炎和某些血液系統腫瘤。在藥物研發領域,針對FCAR的抑制劑被開發用于治療過敏性疾病,如抗IgE抗體和FCAR單克隆抗體,以減少IgE介導的過度炎癥反應。目前,相關藥物已進入臨床試驗階段,顯示出良好的治療效果和安全性。
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驗證數據

The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA258899(FCAR Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: ×200)

The image on the left is immunohistochemistry of paraffin-embedded Human prostate cancer tissue using CSB-PA258899(FCAR Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: ×200)

Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: Mouse brain tissue, Primary antibody: CSB-PA258899(FCAR Antibody) at dilution 1/700, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 10 seconds
FCAR Antibodies
FCAR for Homo sapiens (Human)
產品貨號 | 產品名稱 | 種屬反應性 | 應用類型 |
---|---|---|---|
CSB-PA008531GA01HU | FCAR Antibody | Human | ELISA,WB |
CSB-PA006140 | FCAR Antibody | Human | WB, ELISA |
CSB-PA258899 | FCAR Antibody | Human,Mouse | ELISA,WB,IHC |
CSB-PA573035 | FCAR Antibody | Human,Mouse | ELISA,WB,IHC |
FCAR Proteins
FCAR Proteins for Homo sapiens (Human)
產品貨號 | 產品名稱 | 來源 |
---|---|---|
CSB-YP008531HU1 CSB-EP008531HU1 CSB-BP008531HU1 CSB-MP008531HU1 CSB-EP008531HU1-B |
Recombinant Human Immunoglobulin alpha Fc receptor (FCAR), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CSB-CF008531HU | Recombinant Human Immunoglobulin alpha Fc receptor (FCAR) | in vitro E.coli expression system |