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FADD

FAS相關(guān)死亡區(qū)結(jié)構(gòu)域蛋白是由FADD基因編碼的人類蛋白質(zhì)。它作為一種凋亡適配分子,將半胱氨酸蛋白酶8或半胱氨酸蛋白酶10招募到活化的Fas(CD95)或TNFR-1受體上。形成的復(fù)合物稱為死亡誘導(dǎo)信號(hào)復(fù)合物(DISC),并對(duì)半胱氨酸蛋白酶8進(jìn)行蛋白酶活化。活性半胱氨酸蛋白酶8啟動(dòng)介導(dǎo)細(xì)胞凋亡的下一級(jí)半胱氨酸蛋白酶級(jí)聯(lián)反應(yīng)。該蛋白質(zhì)參與干擾素介導(dǎo)的抗病毒免疫應(yīng)答,在干擾素信號(hào)轉(zhuǎn)導(dǎo)的正向調(diào)控中發(fā)揮作用。
FAS-associated death domain protein is a protein in humans that is encoded by FADD gene. Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.

FADD Antibodies

FADD for Homo sapiens (Human)

FADD for Mus musculus (Mouse)

FADD Proteins

FADD Proteins for Escherichia coli (strain K12)

FADD Proteins for Escherichia coli O6

FADD Proteins for Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)

FADD Proteins for Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)

FADD Proteins for Salmonella typhi

FADD Proteins for Homo sapiens (Human)

FADD Proteins for Drosophila pseudoobscura pseudoobscura (Fruit fly)

FADD Proteins for Mus musculus (Mouse)

FADD Proteins for Bos taurus (Bovine)

FADD Proteins for Escherichia coli O157:H7

FADD Proteins for Yersinia pestis

FADD Proteins for Drosophila melanogaster (Fruit fly)

FADD ELISA Kit

FADD ELISA Kit for Homo sapiens (Human)