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F3

F3,即組織因子,別名CD142、TF、TFA。它是由263個氨基酸殘基組成的跨膜單鏈糖蛋白,分子量約為47 kDa。F3的作用機制是通過與因子VII/VIIa結合啟動血液凝固級聯反應。它與細胞膜緊密結合,發揮“錨”作用,使生理性凝血過程局限于損傷部位。F3可以同時激活凝血因子Ⅸ和Ⅹ,啟動內、外源性兩種凝血酶聯放大反應,在血栓形成過程中起著重要作用。然而,在生理濃度時,F3和FⅦ單獨存在都不具有促凝活性。F3在腫瘤患者中常伴有血液凝固性增強,并且在腫瘤組織中也常見血栓的形成,這可能與腫瘤血管內皮細胞和腫瘤細胞上組織因子F3的異常高表達相關。F3的高表達直接影響細胞增殖、組織浸潤性、轉移性等生物學特征,已成為腫瘤研究中頗具潛力的治療靶標。

熱銷產品

Recombinant Human Tissue factor(F3),partial (Active) (CSB-MP007928HU2)

驗證數據

CSB-MP007928HU2

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

CSB-MP007928HU2

Activity
Measured by its binding ability in a functional ELISA. Immobilized Human TF at 2 μg/ml can bind Anti-TF recombinant antibody (CSB-RA007928MA2HU). The EC50 is 1.434-1.635 ng/mL.

CSB-MP007928HU2

The purity of F3 was greater than 95% as determined by SEC-HPLC

Recombinant Human Serotransferrin(TF) (Active) (CSB-MP023412HU)

驗證數據

CSB-MP023412HU

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

CSB-MP023412HU

Activity
Measured by its binding ability in a functional ELISA. Immobilized TFRC(CSB-MP3648HU)at 2μg/mL can bind Human TF,the EC50 is 58.72-77.84 ng/mL.

Recombinant Macaca fascicularis Tissue factor (F3), partial (Active) (CSB-MP6582MOV)

驗證數據

CSB-MP6582MOV

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

CSB-MP6582MOV

Activity
Measured by its binding ability in a functional ELISA. Immobilized Macaca fascicularis F3 at 2 μg/ml can bind Anti-F3 recombinant antibody (CSB-RA007928MA2HU). The EC50 is 0.4495-0.5538 ng/mL.

F3 Antibodies

F3 for Homo sapiens (Human)

F3 Proteins

F3 Proteins for Homo sapiens (Human)

F3 Proteins for Mus musculus (Mouse)

F3 Proteins for Oryctolagus cuniculus (Rabbit)

F3 Proteins for Bos taurus (Bovine)

F3 Proteins for Microplitis demolitor bracovirus (isolate Webb) (MdBV)

F3 Proteins for Cavia porcellus (Guinea pig)

F3 ELISA Kit

F3 ELISA Kit for Homo sapiens (Human)

F3 ELISA Kit for Rattus norvegicus (Rat)

F3 ELISA Kit for Mus musculus (Mouse)